RecruitingPhase 3NCT06717685

Efficacy of Adenosine as Compared to Verapamil in Paroxysmal Supraventricular Tachycardia (pSVT) Patients

Comparison of Verapamil With Adenosine After Vagal Maneuvers in Patients Presenting With Paroxysmal Supraventricular Tachycardia (pSVT), in a Tertiary Care Hospital of Lahore, Pakistan


Sponsor

Rashid Latif Medical College

Enrollment

210 participants

Start Date

Oct 28, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Supraventricular tachycardia (SVT) is a term widely used to describe tachycardial dysrhythmias, paroxysmal SVT (PSVT) is a narrow term including only AV nodal re-entrant tachycardia (AVNRT) and atrioventricular re-entrant tachycardia (AVRT), both of which can cause discomfort and, in some cases, life-threatening symptoms. Usually Carotid sinus massage is done to lower the pulse rate and after the standard time specific verapamil dose is administered. In this study after carotid sinus massage Conventional Valsalva or modified Valsalva maneuver will be randomly applied. In case, the normal sinus rhythm (NSR) is not achieved then verapamil of or adenosine dose will be administered to the patients after after taking the consent.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Inclusion Criteria3

  • Stable SVT (not requiring cardioversion, fully conscious, maintaining systolic blood pressure of \>90mmHg)
  • Alert enough and able to give consent
  • Able to lie flat and non-painful legs during passive leg raising

Exclusion Criteria8

  • Unstable SVT (Semiconscious, drowsy, breathless, systolic BP \<90mmHg)
  • Not able to give consent
  • Orthopnea causing inability to lie flat
  • Atrial fibrillation/atrial flutter
  • Recent MI (within last 7 days)
  • Ongoing ischemia as indicated by chest pain or ST segment depression/elevation in ECG
  • Aortic stenosis
  • All trimesters of pregnancy

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Interventions

DRUGAdenosine

Adenosine is a medication belonging to class V antidysrhythmics, used to treat a type of irregular heart rhythm disorder known as paroxysmal supraventricular tachycardia (PSVT)

DRUGVerapamil Injection

Verapamil is in a class of medications called calcium-channel blockers. It works by relaxing the blood vessels so the heart does not have to pump as hard. It also increases the supply of blood and oxygen to the heart and slows electrical activity in the heart to control the heart rate.


Locations(1)

Punjab Institute of Cardiology

Lahore, Punjab Province, Pakistan

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NCT06717685