School-based Program for the Prevention of Rheumatic Heart Disease in Endemic Regions
Effectiveness of an Integrated Program for the Prevention of Rheumatic Heart Disease in Endemic Regions: a Stepped Wedge Cluster Randomized Trial
Thomas Pilgrim
6,000 participants
Dec 15, 2024
INTERVENTIONAL
Conditions
Summary
The overall objective of the PREVENT trial is to evaluate the effectiveness of an integrated, school-based program for the prevention of rheumatic heart disease (RHD) in regions with an endemic pattern of RHD. We conduct a stepped wedge cluster randomized trial in randomly selected schools in Nepal and Zambia. The intervention will be delivered at the level of the school and consists in the introduction of a dedicated school-nurse program providing health care through education about RHD, assessment, intervention, and follow-up of GABHS pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with RHD.
Eligibility
Inclusion Criteria1
- \- Children aged 5-16 years
Exclusion Criteria2
- Children / primary caregivers not providing informed consent to participate
- Children not attending one of the selected schools
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Interventions
The intervention consists in the introduction of a school-nurse program providing health care through education about rheumatic heart disease, assessment, intervention, and follow-up of group A beta-hemolytic streptococcal pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with rheumatic heart disease.
Locations(2)
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NCT06720272