RecruitingNot ApplicableNCT06722807

ClAmpless, Sutureless PartIAl Nephrectomy for Renal Masses

ClAmpless, Sutureless PartIAl Nephrectomy for Renal Masses (CASPIAN)

Sponsor

University of Florida

Enrollment

59 participants

Start Date

Jun 10, 2025

Study Type

INTERVENTIONAL

Conditions

Renal Cell Carcinoma (RCC)

Summary

During partial nephrectomy surgery, efforts at minimizing ischemia while maximizing renal parenchymal volume are desirable to preserve renal function1,2. Not only clamping of the hilum but the renorrhaphy portion of the procedure also can have a significant negative impact on renal function3-5. It is possible to perform this procedure without clamping the hilum and also without formal renorrhaphy. However robust prospective formal evaluation of safety, risks, and potential benefits and whether or not the technique can be employed in a generalized fashion has not been studied. Demonstration of safety and generalizability may open a whole new avenue of approaching nephron sparing and renal function sparing kidney surgery and decrease potential risks for long term kidney disease in patients with renal masses. This study will investigate the safety, efficacy, and generalizability of the use of clampless, sutureless partial nephrectomy in the treatment of renal cell carcinoma.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study evaluates a surgical technique for partial kidney removal (partial nephrectomy) that avoids clamping the kidney's blood supply and uses no sutures, potentially reducing complications and preserving kidney function. **You may be eligible if...** - Age 18 or older - Scheduled for partial kidney removal for a tumor 7 cm or smaller - Have only one active cancer at the time of enrollment **You may NOT be eligible if...** - You have more than one active cancer that would complicate the surgery or recovery - You do not meet surgical criteria for partial nephrectomy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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