Assessment of Nebulized Tranexamic Acid in Functional Endoscopic Sinus Surgery Using Modena Bleeding Score
Assessment of Nebulized Tranexamic Acid in Functional Endoscopic Sinus Surgery Using Modena Bleeding Score. a Randomized Double Blinded Controlled Trial.
Assiut University
90 participants
Jan 29, 2025
INTERVENTIONAL
Conditions
Summary
The aim of this study is to investigate the effect of preoperative administration of intravenous or nebulized tranexamic acid on surgical field, blood loss, anesthetic consumption and hemodynamics of patients undergoing FESS. Primary outcome Modena Bleeding Score (MBS) assessing surgical field Secondary outcome 1. Patient hemodynamics. 2. Anesthetic consumption, Extra doses of fentanyl and propofol and sevoflurane\>2 3. Postoperative complications: including any adverse effects to TXA e.g.nausea, vomiting, any visual disturbances, fits, and any thrombotic manifestation.
Eligibility
Inclusion Criteria4
- Either sex
- age 18-65 years
- ASA I-II who are listed for elective functional endoscopic sinus surgery (FESS) under general anesthesia
- normal accepted coagulation profile and hematocrit value ≥30
Exclusion Criteria11
- • chronic renal failure
- liver cirrhosis
- bleeding disorders
- current anticoagulant therapy
- pregnancy or breastfeeding
- impaired color vision
- severe vascular ischemia
- history of venous thrombosis, pulmonary embolism
- long term treatment with acetylsalicylic acid or non-steroidal anti-inflammatory drugs not discontinued before surgery
- hemoglobin (HB) concentration \<10 mg/dl \_allergy to TXA.
- BMI \> 35 kg/ m2
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Interventions
To see if nebulised TXA is better to control blood loss in functional Endoscopic sinus surgery
To see if intravenous TXA is better to control blood loss in functional Endoscopic sinus surgery
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06725732