RecruitingNCT06726720

UmbREALung - A Retrospective and Prospective, Observational, Real World Multi-cohort Study of Patients With Non-small Cell Lung Cancer (NSCLC) Initiating Approved Drugs Developed by AZ or as Part of an AZ Alliance

A Prospective, Observational, Real World Multi-cohort Study of Patients With Non-small Cell Lung Cancer (NSCLC) Initiating AstraZeneca (or Alliance Developed) Drugs


Sponsor

AstraZeneca

Enrollment

300 participants

Start Date

Dec 16, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

This is an ambispective, observational, multicenter and multicohort study, targeting patients with NSCLC initiating approved drugs developed by AZ or as part of an AZ alliance, in the participating countries, as monotherapy or in combination at any stage of disease. Three cohorts are designed, based on the stage of NSCLC (resectable, unresectable and metastatic). The multicohort study is modular in design. Specific modules will be set up separately to assess each new indication of drugs developed by AZ or as part of an AZ alliance once European marketing authorization (MA) has been granted and made available in the participating countries. Patients will be enrolled in the study if they have received (retrospective), receive (retrospective and prospective) or will receive (prospective) approved drugs developed by AZ or as part of an AZ alliance according to the eligibility criteria. Treatment plan and decision are made independently by each treating physician prior to inclusion in this study.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is tracking real-world outcomes for people with non-small cell lung cancer (NSCLC) who are being treated with certain approved medications. Researchers want to understand how these treatments work in everyday clinical practice, not just in controlled lab settings. **You may be eligible if...** - You are 18 or older - You have been diagnosed with non-small cell lung cancer (confirmed by a tissue or cell test) - You recently started (within the past 3 weeks) or are currently on an approved lung cancer drug made by AstraZeneca or through an AZ partnership - You are able to give informed consent **You may NOT be eligible if...** - You are currently enrolled in another interventional clinical trial for NSCLC - You are already participating in another part of this same study - You are under legal guardianship or protection that limits your ability to consent independently Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(52)

Research Site

Aix-en-Provence, France

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Angers, France

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Aurillac, France

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Auxerre, France

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Avignon, France

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Bezannes, France

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Béziers, France

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Blois, France

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Bordeaux, France

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Bourg-en-Bresse, France

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Caen, France

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Carcassonne, France

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Chalon Sur Sa Ne, France

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Chambéry, France

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Châteauroux, France

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Créteil, France

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Dieppe, France

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Dinan, France

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Dreux, France

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Epagny METZ Tessy, France

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Fort de France Cedex, France

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Le Coudray, France

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Limoges, France

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Lyon, France

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Marseille, France

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Marseille, France

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Marseille, France

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Meaux, France

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Metz, France

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Metz, France

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Mulhouse, France

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N MES, France

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Nancy, France

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Nantes, France

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Neuilly-sur-Seine, France

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Nice, France

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Perpignan, France

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Reims, France

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Rouen, France

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Saint-Brieuc, France

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Saint-Etienne, France

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Saint-Herblain, France

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Saint-Priest-en-Jarez, France

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Strasbourg, France

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Suresnes, France

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Toulouse, France

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Troyes, France

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Valenciennes, France

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Vandœuvre-lès-Nancy, France

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Vannes, France

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Villefranche-sur-Saône, France

Research Site

Villeurbanne, France

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NCT06726720