Pharmacokinetic Study of Tranexamic Acid
Pharmacokinetic Study and Clinical Efficacy Observation of Different Routes of Tranexamic Acid Infusion in Advanced Ovarian Cancer Cell Reduction Surgery
Zhejiang Cancer Hospital
30 participants
Nov 20, 2024
INTERVENTIONAL
Conditions
Summary
Tranexamic acid is an effective anti fibrinolytic drug. Clinical studies have found that intravenous injection of tranexamic acid is more effective in reducing blood loss and transfusion in patients with advanced ovarian cancer, without increasing the risk of postoperative complications. Different surgeries and administration routes have an impact on the pharmacokinetics and pharmacodynamics of TXA. At present, there is little data on the pharmacokinetics of intramuscular injection of TXA, and almost all of the data comes from males. For ovarian cancer patients, there are currently no reports on the pharmacokinetics of TXA through different routes of administration, such as intramuscular and intravenous administration. Therefore, the investigators chose ovarian cancer patients and administered it through different routes of intravenous and intramuscular injection.
Eligibility
Inclusion Criteria4
- Adult women aged 20-64 diagnosed with advanced ovarian cancer undergoing cytoreductive surgery
- The cancer stage is III-IV
- ASA classification II-III
- Surgical duration\>2 hours
Exclusion Criteria6
- Renal dysfunction (serum creatinine\>200 mmol/L) or liver dysfunction (Child Turcote classification\>6)
- Has a history of serious mental illness or disorders, epilepsy, visual impairment
- Previous or current bleeding disorders, coagulation dysfunction, or thromboembolic events
- Lower limb venous thrombosis
- Anticoagulants or antifibrinolytic drugs used before surgery within the past month
- Allergic to TXA
Interventions
A slow intravenous infusion of 1g TXA was administered at a rate of about 1ml/min.
5ml intramuscular injections of TXA with twice, each injection time no more than 30 seconds, the injection site was selected as triangle
Locations(1)
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NCT06728670