RecruitingNCT06730503

Glycoprotein in Immunotherapy Response and Efficacy Prediction of Lung Cancer

Sugar Chain Heterogeneity in Immunotherapy Response and Efficacy Prediction of Lung Cancer


Sponsor

Shanghai Chest Hospital

Enrollment

250 participants

Start Date

Oct 1, 2023

Study Type

OBSERVATIONAL

Summary

Immunotherapy has improved the prognosis of non-small cell lung cancer (NSCLC) patients, but about 80% of patients do not respond at all (primary resistance), and some patients initially respond to immunotherapy, later relapse and develop disease progression (acquired resistance). So the objective of this research is to explore the sugar chain heterogeneity of primary and acquired resistance to immunotherapy in patients with NSCLC.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether a certain type of protein found in the blood (a glycoprotein) can predict how well immunotherapy will work for people with advanced lung cancer. Researchers will measure this protein before and after treatment to see if it helps forecast patient outcomes. **You may be eligible if...** - You have been diagnosed with advanced non-small cell lung cancer (NSCLC) - You are currently receiving immunotherapy (a PD-1 or PD-L1 inhibitor) - You are in generally good physical condition and able to carry out normal activities - You have at least one measurable tumor on imaging - You are able to provide blood samples before and after treatment - Your life expectancy is at least 12 weeks **You may NOT be eligible if...** - You are unable to provide blood samples as required - Your organ function (blood counts, liver, kidneys) is not adequate - You are unable to give informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGImmune checkpoint inhibitor

Observe a situation before and after immunotherapy


Locations(1)

Xiaomin Niu

Shanghai, Shanghai Municipality, China

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NCT06730503