RecruitingNot ApplicableNCT06731439

Does Starting Feeds on the First Day of Life Help Premature Infants Reach Full Volume Feeds Sooner?


Sponsor

University of Tennessee

Enrollment

248 participants

Start Date

Jun 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Feeding advancements in ELBW infants have evolved over decades. The fear of causing mortality and morbidity, notably NEC, have made providers cautious when advancing feeds. ELBW infants initially remained NPO for several days before initiating trophic feeds. However, data then showed that there was no increase in mortality and morbidity if trophic feeds were initiated earlier. Then data showed that a short duration of trophic feeds did not increase mortality and morbidity when compared to a prolonged duration. More recent data showed that enteral feeding should be initiated early, preferably within 24 hours of birth, because it may promote feeding tolerance, shorten the time to reach total enteral feeding, and reduce the incidence of extrauterine growth restriction and late onset sepsis without increasing the risk of developing NEC. The management of enteral nutrition in ELBW infants is still very variable. For example, there is no consensus on the optimal time point after birth at which enteral nutrition can be started. This study evaluates the benefits of starting feeds by 6 hours of life Purpose: The primary aim of this study is to evaluate if in infants ≤ 1000g birth weight, is there a benefit initiating feeds by 6 hours of life (compared to current feeding practice data of 3 days of life) on decreasing the time to attain full feeds in the first 30 days of life. The secondary aim is to evaluate if antenatal feeding discussions would streamline feeding management post-delivery.


Eligibility

Min Age: 1 MinuteMax Age: 6 Hours

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Standard feeding protocol and Starting feeds within 6 hours of life for people with extra uterine growth restriction, premature infant disease, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 1 Minute to 6 Hours.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERStarting feeds within 6 hours of life

Starting feeds within 6 hours of life

OTHERStandard feeding protocol

Starting feeds based on standard protocol as per primary team


Locations(1)

Regional One Health

Memphis, Tennessee, United States

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NCT06731439


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