The Efficacy and Safety of HRS8179 in Severe Cerebral Edema Following Large Hemispheric Infarction
The Efficacy and Safety of Intravenous HRS8179 for the Prevention and Treatment of Severe Cerebral Edema Following Large Hemispheric Infarction: a Multicenter, Randomized, Double-blind, Placebo-controlled, Phase II/III Clinical Trial
Beijing Suncadia Pharmaceuticals Co., Ltd
725 participants
Feb 7, 2025
INTERVENTIONAL
Conditions
Summary
The study is being conducted to evaluate the efficacy, and safety of HRS8179 injection in preventing and treating severe cerebral edema after large area cerebral infarction in the cerebral hemisphere
Eligibility
Inclusion Criteria5
- Fully understand and voluntarily participate in this trial, and sign the informed consent form (the informed consent form can be signed voluntarily by the participant or their legal representative);
- A clinical diagnosis of acute ischemic stroke in the middle cerebral artery (MCA) territory;
- National Institutes of Health Stroke Scale (NIHSS) ≥ 10 at screening;
- A large hemispheric infarction defined as: lesion volume of 80 to 160 cm3 on magnetic resonance imaging (MRI) diffusion-weighted imaging (DWI), or computed tomography perfusion (CTP).
- The time from onset to treatment must be ≤ 10 hours; if the onset time is unknown, treatment must be initiated within 10 hours after the time last known normal.
Exclusion Criteria3
- Theparticipant is likely to withdraw the supportive treatment on the first day;
- There is evidence indicating a concurrent infarction in the contralateral hemisphere sufficiently serious to affect functional outcome.
- There are clinical signs of brain herniation; CT/MRI indicates a midline shift of >2 mm; CT/MRI indicates cerebral hemorrhage;
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Interventions
HRS8179 injection; high dose
HRS8179 blank preparation.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06732648