RecruitingNot ApplicableNCT06733376

Evaluating Evidenced Based Options for PTSD Treatment

Evaluating Evidence Based Options for Initial PTSD Treatment Non-Responders

Sponsor

Rush University Medical Center

Enrollment

400 participants

Start Date

Oct 6, 2025

Study Type

INTERVENTIONAL

Conditions

PTSD - Post Traumatic Stress Disorder

Summary

This study will look at: How practical it is to offer another round of proven therapy. How effective different therapy options are for people who didn't respond to the first treatment. The goal is to improve personalized care by: Identifying factors that might predict how someone will respond to a second treatment. Creating a simple tool to spot people who might not respond to treatment early, so they can start a different option sooner. The findings will help improve PTSD care by offering better follow-up treatments and matching patients with the approach that works best for them.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing different evidence-based therapies for PTSD — including Cognitive Processing Therapy (CPT) and Prolonged Exposure (PE) — to see which works best for different people. Participants will be assigned to a treatment and assessed at multiple points. **You may be eligible if...** - You are 18 or older and fluent in English - You have experienced a traumatic event in your lifetime - You have been diagnosed with PTSD (confirmed by a clinical interview) - You are motivated to receive treatment and can attend 10 therapy sessions within 2 weeks - You are willing to complete assessments at multiple timepoints throughout the study **You may NOT be eligible if...** - Your traumatic event occurred within the past month - You are currently at imminent risk of suicide or violence - You have an untreated, unmanaged psychiatric condition that requires stabilization first (e.g., active psychosis) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALCognitive Processing Therapy

Cognitive Processing Therapy is a first-line intervention for the treatment of PTSD that focuses on changing unhelpful patterns of thinking.

BEHAVIORALProlonged Exposure

Prolonged Exposure is an evidence-based treatment for PTSD that helps to reduce the intensity of distress by gradually exposing participants to trauma-related memories, feelings, and situations in real life.

BEHAVIORALSkills Training for Affective and Interpersonal Regulation

Skills Training for Affective and Interpersonal Regulation (STAIR) is a evidence-based treatment geared towards helping regulate emotional and interpersonal needs of those with PTSD.