Exercise Preconditioning to Protect Against Dialysis-induced Cardiac Injury
Exercise Preconditioning to Protect Against Dialysis-induced Cardiac Injury in Hemodialysis Patients: a Randomized Controlled Trial
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
30 participants
Jan 20, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this study is to determine what happens to the heart muscle contraction when people cycle before their hemodialysis treatment. Will pre-dialysis exercise protect the heart from a decrease in pumping of the heart muscle (called stunning) that can happen during hemodialysis. We will study whether pre-dialysis exercise decreases heart stunning, decreases the number and severity of symptoms commonly associated with hemodialysis, and other outcomes
Eligibility
Inclusion Criteria4
- must be on chronic hemodialysis for at least 3 months
- age 18 years or older
- willing and able to provide informed consent
- assessed to be safe and able to exercise by unit HD Nephrologist
Exclusion Criteria8
- regular vigorous exercise outside of hemodialysis
- over 79 years of age
- intradialytic exercise < 3 months
- poor echogenicity
- acute coronary syndrome in the past 3 months
- unstable arrhythmia/angina
- shortness of breath at rest or with minimal activity
- symptomatic hypoglycemia (>2x/week in the week prior to enrolment)
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Interventions
The impact of interdialytic exercise on cardio protection during HD has never been studied. This approach may enhance cardiovascular benefits and overall physical fitness, thereby contributing to better health outcomes in individuals undergoing HD.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06735378