RecruitingPhase 1Phase 2NCT06735495

CD19 & CD22 Bispecific CAR T Cells in the Treatment of Relapsed/Refractory B Cell Hematologic Tumors

The Safety and Efficacy of CD19 & CD22 Bispecific CAR T Cells in Treating Relapsed / Refractory B Cell Hematological Tumors


Sponsor

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Enrollment

80 participants

Start Date

Nov 4, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study is a multi-center, open, prospective single-arm clinical study of patients with relapsed / refractory B cell hematological tumors to evaluate the safety and efficacy of CD19 \& CD22 bispecific CAR-T cells in relapsed / refractory B cell hematological tumors while collecting pharmacokinetics and pharmacodynamics indicators of CAR-T cells.


Eligibility

Min Age: 3 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a bispecific CAR T-cell therapy — immune cells engineered to attack cancer cells carrying two different markers (CD19 and CD22) — in people with B-cell blood cancers that have come back or stopped responding to treatment. **You may be eligible if...** - You have CD19+ and CD22+ B-cell blood cancer (such as B-cell leukemia or lymphoma) confirmed by testing - Your cancer has relapsed (come back) or is refractory (no longer responding) - You may qualify if you relapsed within 6 months of first remission, didn't respond to standard chemotherapy, or are not eligible for a stem cell transplant **You may NOT be eligible if...** - Your cancer is not CD19+ or CD22+ - You are in good remission and do not require further therapy - You have organ problems that make this treatment unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCD19&CD22 bispecific CAR-T cells

Each patient will receive CD19\&CD22 bispecific CAR-T cells by intravenous infusion on day 0


Locations(1)

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, China

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NCT06735495


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