RecruitingNot ApplicableNCT06735924

Influence of Metabolic Syndrome on Endogenous Oxalate Synthesis

Non Alcoholic Fatty Liver Disease and Endogenous Oxalate Synthesis

Sponsor

University of Alabama at Birmingham

Enrollment

28 participants

Start Date

Apr 26, 2023

Study Type

INTERVENTIONAL

Conditions

MASLD Metabolic Dysfunction-Associated Steatotic Liver Disease

Summary

This study aims to determine the daily rate of endogenous synthesis of oxalate using fasted urine collection and a low-oxalate controlled diet in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).

Eligibility

Min Age: 18 Years

Inclusion Criteria5

age \>18 years
History of MASLD, with liver fat content \> 5%
Normal kidney function
Stable medication for at least 1 month for diabetes mellitus if any
Willingess to ingest fixed diets and stop dietary supplements for the study and come to UAB for visits

Exclusion Criteria18

Age \< 18 years
Inaccurate 24-hour urine collections
Liver fat content \<5%
Liver cirrhosis
Evidence of other chronic liver disease, viral hepatitis
history of alcoholism within 2 years of enrollment
Contra-indication to Magnetic Resonance Imaging
Chronic kidney disease with estimated Glomerular Filtration rate \< 60 ml/min/1.73m2
Type 1 Diabetes Mellitus or treatment with insulin
Uncontrolled diabetes
Pregnancy, lactation or intention to be
Uncontrolled hypertension
Use of weight loss medication, SGLT2 inhibitors, GLP-1 receptor agonists, osteoporosis medication, chronic NSAID
History of gastric or intestinal surgery or resection that could potentially alter oxalate absorption
Chronic fat malabsorption
Use of immunosuppressive medications
Known immuno-compromised status
Active malignancy or treatment for malignanacy within the last 12 months