MASLD Clinical Trials

18 recruiting

MASLD Trials at a Glance

32 actively recruiting trials for masld are listed on ClinicalTrialsFinder across 6 cities in 20 countries. The largest study group is Not Applicable with 15 trials, with the heaviest enrollment activity in La Jolla, San Francisco, and Boston. Lead sponsors running masld studies include Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), University of California, San Diego, and University of California, San Francisco.

Browse masld trials by phase

Treatments under study

About MASLD Clinical Trials

Looking for clinical trials for MASLD? There are currently 18 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new MASLD trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about MASLD clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 32 trials

Recruiting
Phase 2

Investigation of the Efficacy of a Probiotic Mixture in Moderate Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Mechanistic Trial

MASLD - Metabolic Dysfunction-Associated Steatotic Liver DiseaseFatty Liver Disease, NonalcoholicOverweight (BMI > 25)
AB Biotics, SA60 enrolled1 locationNCT07193927
Recruiting
Not Applicable

Rehabilitation With Exercise-Based Intervention for Nonalcoholic Chronic Hepatic Esteatosis

Metabolic Associated-dysfunction Steatotic Liver Disease (MASLD)Metabolic Adaptation to High-Intensity Interval Training
Universidad San Sebastián30 enrolled1 locationNCT07552727
Recruiting
Not Applicable

Time-restricted Feeding in MASLD

Metabolic Associated-dysfunction Steatotic Liver Disease (MASLD)
Universität des Saarlandes120 enrolled1 locationNCT07530809
Recruiting

Accurate Point of Care Liver Disease Diagnostics (Phase 2)

MASLD
University of California, San Diego26 enrolled1 locationNCT07518784
Recruiting

Expanded Studies on the SCAPIS Stockholm Reexamination Cohort

Heart FailureCoronary Artery DiseaseOral Microbiota+9 more
Danderyd Hospital1,400 enrolled1 locationNCT07476703
Recruiting

Spleen Stiffness Measurement for the Detection of Advanced Fibrosis

MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
Fondazione Policlinico Universitario Agostino Gemelli IRCCS500 enrolled1 locationNCT07440511
Recruiting

Quantitative Ultrasound to Assess Steatotic Liver Disease in Children

MASLDMASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
University of California, San Diego120 enrolled1 locationNCT06706856
Recruiting

Study of PNPLA3 Genetic Polymorphisms in Patients With Non-Alcoholic Fatty Liver Disease in an Ultramarine Population (AdipoDROMExpo)

MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis)
Centre Hospitalier Universitaire de la Guadeloupe600 enrolled3 locationsNCT07330830
Recruiting

Thermoacoustic Method for Estimating Liver Fat Fraction

MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis)Fatty Liver Disease, Nonalcoholic
Endra Lifesciences49 enrolled1 locationNCT07321925
Recruiting
Not Applicable

Hepatic Gene Response to Intravenous Glucose in Obese Patients With and Without MASLD Undergoing Bariatric Surgery

MASLD
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)40 enrolled1 locationNCT07326865
Recruiting
Not Applicable

Influence of Metabolic Syndrome on Endogenous Oxalate Synthesis

MASLDMetabolic Dysfunction-Associated Steatotic Liver Disease
University of Alabama at Birmingham28 enrolled1 locationNCT06735924
Recruiting
Not Applicable

High Fructose Diet, the Gut Microbiome, and Metabolic Health

ObesityMASLDType 2 Diabetes
Icahn School of Medicine at Mount Sinai30 enrolled1 locationNCT06329544
Recruiting
Not Applicable

Corazones Unidos Study

CVD - Cardiovascular DiseaseMASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
University of Arizona45 enrolled1 locationNCT07298213
Recruiting

The Development of MASLD Among Survivors of Breast or Colorectal Cancer

Breast Cancer SurvivorsColorectal (Colon or Rectal) Cancer SurvivorsMASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis)
University of Bern200 enrolled1 locationNCT07280143
Recruiting
Not Applicable

Development of a Quantifiable Ultrasound Biomarker for Hepatic Steatosis

NAFLD - Non-Alcoholic Fatty Liver DiseaseMASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
ContextVision AB110 enrolled1 locationNCT07270601
Recruiting
Not Applicable

Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

Insulin Sensitivity/ResistanceObesityInsulin Resistance+14 more
Pichamol Jirapinyo, MD, MPH132 enrolled2 locationsNCT06138821
Recruiting
Not Applicable

DEFINITION OF THE GENOMIC LANDSCAPE OF MASLD

CirrhosisMASLD
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico2,880 enrolled1 locationNCT07249112
Recruiting
Not Applicable

NAFLD Clinical Care Pathway

MASLDNAFLD
VA Office of Research and Development32 enrolled1 locationNCT06671886
Recruiting
Phase 2

Effect of Ketone Esters on Liver Fat Content and Metabolic Function

ObesityOverweight (BMI > 25)MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
Washington University School of Medicine40 enrolled1 locationNCT07097506
Recruiting

Endoscopic Ultrasound Shear Wave Elastography Study

MASLDFibrosis, LiverChronic Liver Disease+1 more
Olympus Corporation of the Americas300 enrolled2 locationsNCT06592820