MASLD Clinical Trials

43 recruitingLast updated: June 17, 2026

There are 43 actively recruiting masld clinical trials across 27 countries. Studies span Not Applicable, Phase 2, Phase 1, Early Phase 1, Phase 4. Top locations include Houston, Texas, United States, San Francisco, California, United States, La Jolla, California, United States. Updated daily from ClinicalTrials.gov.


MASLD Trials at a Glance

43 actively recruiting trials for masld are listed on ClinicalTrialsFinder across 6 cities in 27 countries. The largest study group is Not Applicable with 20 trials, with the heaviest enrollment activity in Houston, San Francisco, and La Jolla. Lead sponsors running masld studies include Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Corcept Therapeutics, and University of California, San Diego.

Browse masld trials by phase

Treatments under study

About MASLD Clinical Trials

Looking for clinical trials for MASLD? There are currently 20 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new MASLD trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about MASLD clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 43 trials

Recruiting
Not Applicable

UNMASK: UNveiling the Pathobiology of Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) for the Discovery of Novel Therapeutics and biomarKers

MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
Fundación Pública Andaluza para la gestión de la Investigación en Sevilla450 enrolled3 locationsNCT07652151
Recruiting
Not Applicable

Effects of Peanut Consumption on Adults With Metabolic Associated Fatty Liver Disease

MASLDFatty Liver
Henry Ford Health System125 enrolled1 locationNCT07646197
Recruiting
Phase 2

Digoxin In NASH (CODIN)

MASLDMASH - Metabolic Dysfunction-Associated SteatohepatitisFatty Liver Disease+5 more
Yale University144 enrolled2 locationsNCT06588699
Recruiting
Phase 1

Evaluating the Pharmacokinetics and Safety of Miricorilant

Nonalcoholic Steatohepatitis (NASH)Non-alcoholic Fatty Liver Disease NAFLDMetabolic Dysfunction-Associated Steatohepatitis (MASH) / Nonalcoholic Steatohepatitis (NASH) With Compensated Cirrhosis+1 more
Corcept Therapeutics15 enrolled1 locationNCT07553663
Recruiting
Not Applicable

EVOO and Metabolic Liver Health in MASLD

OverweightMASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis60 enrolled1 locationNCT07412444
Recruiting
Phase 2

A Study to Evaluate the Use of Resmetirom in Participants With MASLD and HIV

HIV (Human Immunodeficiency Virus)MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
Naga P. Chalasani120 enrolled10 locationsNCT07143968
Recruiting
Phase 2

Investigation of the Efficacy of a Probiotic Mixture in Moderate Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Mechanistic Trial

MASLD - Metabolic Dysfunction-Associated Steatotic Liver DiseaseFatty Liver Disease, NonalcoholicOverweight (BMI > 25)
AB Biotics, SA60 enrolled1 locationNCT07193927
Recruiting
Not Applicable

Rehabilitation With Exercise-Based Intervention for Nonalcoholic Chronic Hepatic Esteatosis

Metabolic Associated-dysfunction Steatotic Liver Disease (MASLD)Metabolic Adaptation to High-Intensity Interval Training
Universidad San Sebastián30 enrolled1 locationNCT07552727
Recruiting
Not Applicable

Effects of Normobaric Hypoxic Training in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

MASLD - Metabolic Dysfunction-Associated Steatotic Liver DiseaseNormobaric Hypoxia
University of Trieste20 enrolled1 locationNCT07073326
Recruiting
Phase 1Phase 2

A Trial to Learn if ALN-PNP is Safe and Well Tolerated in Healthy Adults and Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Healthy VolunteersMetabolic dysfunction–associated steatotic liver disease (MASLD)
Regeneron Pharmaceuticals172 enrolled6 locationsNCT05648214
Recruiting
Not Applicable

Time-restricted Feeding in MASLD

Metabolic Associated-dysfunction Steatotic Liver Disease (MASLD)
Universität des Saarlandes120 enrolled1 locationNCT07530809
Recruiting

Accurate Point of Care Liver Disease Diagnostics (Phase 2)

MASLDNAFLD (Nonalcoholic Fatty Liver Disease)NAFLD+1 more
University of California, San Diego26 enrolled1 locationNCT07518784
Recruiting

Expanded Studies on the SCAPIS Stockholm Reexamination Cohort

Heart FailureCoronary Artery DiseaseOral Microbiota+9 more
Danderyd Hospital1,400 enrolled1 locationNCT07476703
Recruiting

Spleen Stiffness Measurement for the Detection of Advanced Fibrosis

MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
Fondazione Policlinico Universitario Agostino Gemelli IRCCS500 enrolled1 locationNCT07440511
Recruiting
Phase 1

Evaluation of Miricorilant on Liver Fat in Patients With MASLD

Nonalcoholic Steatohepatitis (NASH)Metabolic dysfunction-associated steatohepatitis (MASH)Non-alcoholic Fatty Liver Disease NAFLD+1 more
Corcept Therapeutics8 enrolled1 locationNCT06947304
Recruiting
Not Applicable

Stimulating Fat Tissue Storage With Niacin to Reduce Fat Accumulation in the Liver.

Non alcoholic steato hepatitis (NASH)Liver Fibrosis/NASHMetabolic dysfunction–associated steatotic liver disease (MASLD)
Université de Sherbrooke36 enrolled1 locationNCT06843148
Recruiting

Quantitative Ultrasound to Assess Steatotic Liver Disease in Children

MASLDMASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
University of California, San Diego120 enrolled1 locationNCT06706856
Recruiting

Study of PNPLA3 Genetic Polymorphisms in Patients With Non-Alcoholic Fatty Liver Disease in an Ultramarine Population (AdipoDROMExpo)

MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis)
Centre Hospitalier Universitaire de la Guadeloupe600 enrolled3 locationsNCT07330830
Recruiting

Thermoacoustic Method for Estimating Liver Fat Fraction

MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis)Fatty Liver Disease, Nonalcoholic
Endra Lifesciences49 enrolled1 locationNCT07321925
Recruiting
Not Applicable

Hepatic Gene Response to Intravenous Glucose in Obese Patients With and Without MASLD Undergoing Bariatric Surgery

MASLD
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)40 enrolled1 locationNCT07326865