The Impact of a 48-hour Fast with or Without Exercise on Immune Cell Metabolism and Glycemic Control in Healthy Active Adults
The Impact of a 48-hour Fast with or Without Exercise on Immune Cell Function, Bioenergetics, and Glycemic Control in Healthy Active Adults: a Randomized Crossover Trial
University of British Columbia
15 participants
Jan 10, 2025
INTERVENTIONAL
Conditions
Summary
Many individuals engage in fasting for its purported health benefits but the effects of fasting on immune cell and whole body metabolism are not well understood in humans. Moreover, how exercising during a prolonged fast impacts immunometabolic outcomes is unclear. This study will determine how a 2 day fast - performed with or without daily exercise - impacts immune cell bioenergetics, immune cell function, and whole-body glycemic control in healthy active individuals.
Eligibility
Inclusion Criteria2
- Aged between 19 and 35 years.
- Physically active (engaging in ≥150 minutes of weekly moderate to vigorous physical activity).
Exclusion Criteria8
- History of cardiometabolic diseases or inflammatory diseases (e.g., chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, cardiovascular disease).
- Individuals currently following a ketogenic diet, low-calorie diet, periodic fasting regimen, or consuming ketogenic supplements (e.g., exogenous ketone drinks).
- Cigarette/vaping smoking.
- Physical limitation that will impair the ability of the participant to perform exercise.
- Individuals having a body mass index (BMI) over 30 kg/m2.
- Cancer diagnosis in the past 5 years.
- Taking anti-inflammatory drugs (e.g., ibuprofen, aspirin, naproxen).
- Being unable to read or communicate in English.
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Interventions
Participants will complete a 48-hour fast. One hour of exercise will be performed on each morning of the fast.
Participant will complete a 48-hour fast. No structured exercise will be performed during each of the fasting days.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06737224