RecruitingNot ApplicableNCT06739148

The Enhancement Effect of Low-Level Laser Therapy for Muscle Training with Combined NMES and BFR

The Enhancement Effect of Low-Level Laser Therapy for Muscle Training with Combined Neuromuscular Electrical Stimulation and Blood Flow Restriction

Sponsor

National Cheng-Kung University Hospital

Enrollment

44 participants

Start Date

Oct 1, 2024

Study Type

INTERVENTIONAL

Conditions

Muscle Strength Blood Flow Restriction Therapy Neuromuscular Electrical Stimulation (NMES)Laser Therapy, Low-Level

Summary

Blood flow restriction training (BFR) with neuromuscular stimulation (NMES) is employed for individuals with limited mobility and joint issues. However, this approach is highly susceptible to muscle fatigue, despite its potential beneficial effects on muscle strength. Recently, there has been growing interest in using low-level laser therapy (LLLT) to address muscle fatigue. LLLT, known for improving microcirculation and mitochondrial function, shows promise in alleviating enhanced muscle fatigue associated with combined BFR and NMES training. Despite these positive effects, there is limited knowledge about the short-term training impact of combined BFR and NMES with LLLT preconditioning. This project aims to investigate whether the photobiomodulation effects of LLLT could further enhance the training benefits of combined BFR and NMES. The study will employ an integrated analysis of decomposition surface EMG, EEG, and mechanomyogram to explore the behavior and neuromuscular mechanisms underlying the training benefits. If additional benefits are identified, LLLT pre-conditioning is recommended to enhance the use of combined BFR and NMES.

Eligibility

Min Age: 20 YearsMax Age: 40 Years

Inclusion Criteria2

Healthy adults aged 20-40, without a diagnosis of cardiovascular or neuromusculoskeletal diseases.
Normal vision range after visual correction.

Exclusion Criteria4

Exclude students who have a teacher-student relationship with the principal investigator to ensure the participants\' autonomy.
History of brain injury, stroke, spinal cord injury, or other neuromuscular-related conditions.
Contraindications for laser therapy: pregnancy, malignant tumor tissues, bleeding areas, and photosensitive skin regions.
Presence of any contraindications for blood flow restriction training, such as a history of injury or strain in the non-dominant arm\'s biceps, deep vein thrombosis or venous occlusion in the non-dominant arm, acute unstable fractures in the non-dominant arm, acute regional infections in the non-dominant arm, severe peripheral arterial occlusive disease in the non-dominant arm, complete lymphatic obstruction in the non-dominant arm, and edema due to acute pulmonary edema or congestive heart failure in the non-dominant arm.

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Interventions

DEVICELow Level Laser Therapy

Low-level laser therapy can increase cellular energy production, making it useful as a pre-conditioning treatment to prevent muscle contraction fatigue or as a post-contraction therapy to accelerate fatigue recovery.

DEVICEblood flow restriction

Its advantage is that during training, it can surpass the \"overload principle,\" allowing for effective muscle cross-sectional area growth with relatively light weight training (20%-50% of 1RM or 20%-40% of MVC).

DEVICENeuromuscular Electrical Stimulation

It is a strength training method that uses electrical currents to stimulate nerve and muscle activation, helping to maintain muscle mass, increase blood flow, and slow down or prevent muscle atrophy.