RecruitingNCT06744335
Prospective Observational Multicenter Study of Patients With AH and CKD Markers in Kazakhstan (PROGRESS-CKD)
Prospective Observational Multicenter Study of Patients With Arterial Hypertension and Chronic Kidney Disease Markers in Kazakhstan (PROGRESS-CKD)
Sponsor
AstraZeneca
Enrollment
1,282 participants
Start Date
Jan 20, 2025
Study Type
OBSERVATIONAL
Conditions
Summary
Multicenter, non-interventional PRospective Observational study with retrospective analysis to describe the rate of CKD diaGnosis in patients with aRtErial hypErtenSion and CKD markerS in Kazakhstan
Eligibility
Min Age: 18 Years
Inclusion Criteria6
- Age ≥18 years at the time of inclusion;
- Patient signed and dated written informed consent form (ICF) in accordance with ICH GCP and local legislation prior to inclusion in the study for the prospective observational cohort;
- Established diagnosis of hypertension, diagnosed in accordance with current clinical guidelines for hypertension, i.e. in adults, i.e. systolic blood pressure (SBP) ≥140 mmHg and/or diastolic blood pressure (DBP) ≥90 mmHg. when measured at two different visits
- Laboratory markers of CKD (eGFR \<60 mL/min/1.73 m2 and/or albuminuria/proteinuria\*) measured during the period ≤12 months prior to inclusion in the study and persisting ≥3 months between two measurements without a recorded diagnosis of CKD in the primary medical record prior to inclusion;
- \* any of the following: urine albumin/creatinine ratio (UACR) ≥30 mg/g (3 mg/mmol), Urine protein-creatinine ratio (uPCR) ≥150 mg/g (15 mg/mmol), albuminuria ≥30 mg/d or Urine protein-creatinine ratio (uPCR) ≥0.15 mg/d.
- Absence of documented diagnosis of CKD in the patient's medical records prior to inclusion in the study
Exclusion Criteria5
- Absence of a signed ICF in patients in the prospective follow-up group
- Participation in any randomized controlled trial within 3 months prior to inclusion in this study or during participation in this study
- An established diagnosis of type 1 or type 2 diabetes mellitus.
- Diagnosis of symptomatic chronic heart failure (CHF), NYHA functional class III-IV, documented in the patient's medical records
- Diagnosis of AH of secondary genesis
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06744335