RecruitingNot ApplicableNCT06747364

Phosphatidylethanol and Other Ethanol Consumption Markers

Sponsor

The University of Texas Health Science Center at San Antonio

Enrollment

80 participants

Start Date

Jan 7, 2025

Study Type

INTERVENTIONAL

Conditions

Healthy Volunteer Alcohol Consumption

Summary

This study is intended to help the investigators understand how a biomarker found in the blood may be used to better identify the quantity and different patterns of alcohol use. The investigators hope that the results of this study will help identify the uses of alcohol-use markers in the blood in future alcohol prevention and treatment programs. It is hoped that the information learned from this study will benefit other people in the future. The study participants will come into the lab and will (1) consume alcohol in the lab designed to produce a peak blood alcohol concentration of 0.06% and have blood collected over 6 hours followed by abstinence for 10 days to give a small blood sample 4 times and (2) to give a small amount of blood 5 times within 28 days (naturalistic drinking) and provide answers about alcohol use.

Eligibility

Min Age: 21 Years

Plain Language Summary

Simplified for easier understanding

This study is examining blood and urine markers that can detect how much alcohol a person has consumed. Researchers are testing whether a marker called phosphatidylethanol (PEth) and other biomarkers can accurately reflect alcohol intake. This is a research study, not a treatment trial. **You may be eligible if...** - You are 21 years or older - You have a normal body weight range (BMI between 18 and 30) - You have had at least one drinking occasion in the past month where you reached a mild level of intoxication **You may NOT be eligible if...** - You have signs of alcohol withdrawal - You are currently in alcohol treatment - You have a substance use disorder (other than nicotine or caffeine) - You are pregnant, breastfeeding, or have liver disease - You have a scheduled surgery coming up - You have a serious psychiatric condition involving psychosis or delirium Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERAlcohol (Ethanol)

Alcohol will be administered to participants by research staff. In Phase 1, participants will consume alcohol designed to produce a targeted blood alcohol concentration (BAC) of 0.06% using the modified Widmark equation.

Locations(2)

University of North Texas

Denton, Texas, United States

University of Texas Health Science Center San Antonio

San Antonio, Texas, United States

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NCT06747364

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