RecruitingPhase 4NCT06748209

Establishing Mobile Transcranial Magnetic Stimulation

Portable Transcranial Magnetic Stimulation (TMS) in a Van for Treatment-Resistant Depression

Sponsor

Medical University of South Carolina

Enrollment

30 participants

Start Date

May 10, 2025

Study Type

INTERVENTIONAL

Conditions

Treatment Resistant Major Depression

Summary

In this pilot study, investigators propose to design and create a portable TMS unit, in a van, and then test out delivering TMS in three different locations in South Carolina, all affiliated with MUSC and within 2-hours driving from Charleston, SC. This study would test out this new delivery mode, and provide valuable feasibility, safety, and efficacy lessons for later refinement and potential widespread adoption of mobile TMS as a treatment option, both in our state and across the US.

Eligibility

Min Age: 22 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is exploring whether transcranial magnetic stimulation (TMS) — a non-invasive brain stimulation technique that uses magnetic pulses to stimulate nerve cells — can be delivered at home using a mobile device for people with treatment-resistant depression (depression that hasn't improved with multiple medications). **You may be eligible if...** - You are between 22 and 80 years old - You have treatment-resistant depression, meaning antidepressants have not worked well for you - You are able to read and communicate in English - You can provide your own consent - You have access to a computer with video call capability **You may NOT be eligible if...** - You have unstable medical conditions that would make TMS unsafe (such as poorly controlled seizures) - You have metal implants in your head (e.g., from surgery) - You are pregnant - You are currently struggling with active substance use (other than tobacco) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICELeft prefrontal Transcranial Magnetic Stimulation (TMS)

FDA cleared TMS

DEVICEFDA cleared TMS for treating depression

This is FDA approved TMS

Locations(1)

Medical Univerity of South Carolina

Charleston, South Carolina, United States

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NCT06748209