RecruitingPhase 2NCT06749210

DAANCE FOR CHEMOTHERAPY-INDUCED NEUROPATHY

DANCE-BASED AVENUES TO ADVANCE NONPHARMACOLOGIC TREATMENT OF CHEMOTHERAPY EFFECTS (DAANCE): A MULTICENTER TRIAL

Sponsor

Ohio State University Comprehensive Cancer Center

Enrollment

140 participants

Start Date

Feb 19, 2025

Study Type

INTERVENTIONAL

Conditions

Cancer of the Breast Chemotherapy-induced Neuropathy

Summary

Up to 80% of breast cancer survivors experience chemotherapy-induced neuropathy that impairs quality of life and increases fall risk long into survivorship, yet treatment options for neuropathy remain limited. The successful treatment will target neurophysiologic mechanisms for restoring function while addressing patient-reported symptoms and participation in treatment. Toward this end, the investigators propose to study a noninvasive, social sensorimotor intervention - Adapted Argentine Tango - which targets motor control restoration, symptom alleviation, and treatment participation in concert.

Eligibility

Min Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a structured dance program can help relieve nerve damage (neuropathy) caused by chemotherapy in breast cancer survivors. Chemotherapy-induced neuropathy causes numbness, tingling, and pain — often in the hands and feet — and can also affect balance and increase the risk of falling. **You may be eligible if...** - You have been diagnosed with breast cancer (any stage, including metastatic) - You completed taxane-based chemotherapy (e.g., paclitaxel or docetaxel) at least 3 months ago - You currently experience neuropathy symptoms (self-reported) - Your balance test suggests you may be at risk of falling - You are able to walk (assistive devices are allowed) **You may NOT be eligible if...** - You have a pre-existing inner ear (vestibular) disorder - Your diabetes is poorly controlled (HbA1c of 8% or higher) - You cannot hear well enough to participate (less than 10% bilateral hearing) - Your cancer doctor has advised against physical activity due to another condition (e.g., a herniated disc, unstable bones) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALTango

The intervention being studied is a 16 session intervention (2x4-week modules), delivered over an 8-week period by community-based individuals with expertise in dance and patient care and certified in Adapted Tango or AdapTango dance instruction. Steps available to teach, including order and cues to teach them, are detailed in Hackney's AdapTango manual. All steps are based on the Argentine Tango steps that emerged within working class community centers in Buenos Aires, Argentina (milongas) in the late 1800s and have been adapted by the investigators for use as medical exercise among people with mobility deficits. Of note, Argentine Tango is distinct from, and the precursor for, the American Tango style of competitive ballroom dance: where American Tango highlights showmanship and complicated footwork, Argentine Tango prioritizes connection between partners and musicality within a basic walk motion.