RecruitingNot ApplicableNCT06749392

An Individual-specific Synchrony Signature

An Individual-specific Understanding of How Synchrony Becomes Curative


Sponsor

University of Haifa

Enrollment

78 participants

Start Date

Nov 22, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study aims to establish synchrony as an individual-specific mechanism of therapeutic change and offers novel insights into the mechanisms of curative interpersonal processes. The study identifies individual-specific trait-like synchrony signature and investigates the associations between synchrony signature, the individual's trait-like characteristics, and mental health, among participants diagnosed with Major Depressive Disorder. The study further investigates how deterministic the trait-like synchrony signature is by identifying for whom, how, and when changes are anticipated. Additionally, it examines whether synchrony signature transfers to relationships with the therapist, whether and how it changes throughout treatment, and whether such potential changes are associated with improvements in mental health. Synchrony is recognized as a key driver of collaborative, affiliative, and curative relationships. While its potential role in improving mental health through interpersonal relationships has sparked growing interest, particularly in psychotherapy, the field is at a crossroads, with mixed findings challenging the widespread theoretical assumption that "more synchrony is better." This study introduces a personalized framework that emphasizes individual-specific synchrony signatures, shifting from generalized assumptions to tailored understanding and interventions. The study explores how synchrony can transform relationships into curative ones by leveraging individual-tailored changes in synchrony signatures in psychotherapy. The potential impact is vast. Tailoring synchrony to individual-specific signatures represents a paradigm shift from a one-size-fits-all approach to personalized interventions. This personalized framework could revolutionize mental health care by facilitating the development of targeted strategies that enhance treatment outcomes.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a personalized brain-stimulation treatment called Transcranial Magnetic Stimulation (TMS), tailored to each individual's unique brain patterns (called a 'synchrony signature'), for people with major depression that has not fully responded to medication. The idea is that personalizing the stimulation location could make it more effective. **You may be eligible if...** - You have been diagnosed with major depressive disorder and scored above 14 on a standard depression scale at two separate assessments one week apart - You are between 18 and 65 years old - If you are taking psychiatric medications, your dosage has been stable for at least 3 months - You are proficient in Hebrew **You may NOT be eligible if...** - You are currently at risk of suicide or self-harm - You have an active substance use disorder - You have a history of schizophrenia, psychosis, bipolar disorder, or a severe eating disorder - You have a brain disorder from an identifiable physical cause (organic brain disorder) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALSupportive-expressive treatment

Sixteen weeks of a time-limited psychodynamic therapy adapted for depression that includes the use of expressive techniques, such as interpretation, confrontation, clarification and the use of supportive techniques, such as affirmation and empathic validation. This treatment postulates insight as its core mechanism of change.


Locations(1)

University of Haifa

Haifa, Israel

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NCT06749392


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