Assessment of a Quantra-guided Transfusion Algorithm in Liver Transplantation
University Hospital, Toulouse
56 participants
Mar 8, 2025
INTERVENTIONAL
Conditions
Summary
Liver transplantation carries a substantial risk of bleeding, making precise haemostasis control essential, although assessing coagulation remains challenging. Quantra, a bedside viscoelastic testing device using sonorheometric methods, offers an innovative approach to guiding haemostatic management during surgery. The study aims to determine whether a Quantra-guided transfusion can reduce transfusion and bleeding during liver transplantation when compared to a conventional transfusion approach.
Eligibility
Inclusion Criteria9
- Patients aged 18 years or older
- Patient with ESLD undergoing liver transplantation
- Individuals affiliated with or beneficiaries of a social security scheme
- Free and informed written consent obtained in writing from the patient, or where applicable from the trusted person/family member/close relative
- Multi-organ transplantation
- Congenital haemostasis disorder (such as haemophilia)
- Patient under juridical protection (persons deprived of liberty or under curatorship or guardianship or safeguard of justice)
- Pregnant or breast-feeding woman
- Patient already enrolled in another interventional study with primary or secondary objective of reducing perioperative bleeding or transfusion
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Interventions
In addition to routine coagulation tests, a Quantra Qstat® analysis will be performed at baseline (before incision), at the end of native liver dissection, and after unclamping of the venous anastomoses. In the event of bleeding, additional Quantra Qstat® analyses may be conducted until bleeding control is achieved. Transfusion and administration of blood-derived medications will be guided by the results of the Quantra Qstat® analyses.
Transfusion and blood-derived medications will be guided by the results of routine coagulation tests.
Locations(1)
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NCT06749405