RecruitingNCT06749600

Clinical Management and Outcomes of Primary Ovarian Leiomyosarcoma


Sponsor

Azienda USL Reggio Emilia - IRCCS

Enrollment

30 participants

Start Date

Jun 14, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

This observational study aims to gather comprehensive data on primary ovarian leiomyosarcoma (POLMS). This extremely rare malignancy accounts for less than 3% of primary ovarian malignancies and has an incidence of only 1% among ovarian cancers. This national, retrospective and prospective multicenter study will collect and analyze historical cases of POLMS with remote diagnoses accessed through clinical case reviews and newly identified cases. The study aims to expand a previously identified series of 113 cases described in the literature, uncovering patterns in diagnosis, treatment, and outcomes and ultimately establishing evidence-based guidelines for the optimal management of this rare and aggressive cancer.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 99 Years

Plain Language Summary

Simplified for easier understanding

This study is collecting and analyzing clinical data from patients diagnosed with primary ovarian leiomyosarcoma — an extremely rare type of cancer that starts in the smooth muscle cells of the ovary. Because this cancer is so uncommon, researchers are pooling data from multiple centers to better understand how it behaves and how best to treat it. **You may be eligible if...** - You have been diagnosed with primary leiomyosarcoma (smooth muscle cancer) of the ovary - Relevant diagnosis and treatment data are available in your medical records - You are between 18 and 99 years old **You may NOT be eligible if...** - You have a different type of ovarian sarcoma (such as rhabdomyosarcoma, fibrosarcoma, or stromal cell sarcoma) - You have been diagnosed with leiomyosarcoma of the uterus rather than the ovary Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(10)

AOU Policlinico di Modena

Modena, Italy, Italy

Azienda Ospedaliero Universitaria di Parma - S.C. Ostetricia e Ginecologia

Parma, PR, Italy

Azienda USL IRCCS di Reggio Emilia

Reggio Emilia, RE, Italy

Malzoni - Avellino

Avellino, Italy

Azienda Ospedaliero Universitaria Policlinico "G.Rodolico - San Marco" - Catania

Catania, Italy

IRCCS Ospedale San Raffaele

Milan, Italy

Fondazione Irccs San Gerardo Dei Tintori

Monza, Italy

IRCCS Istituto Nazionale Tumori Fondazione Pascale

Naples, Italy

Università degli Studi di Napoli Federico II

Naples, Italy

Ospedale "Sacro Cuore"

Verona, Italy

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NCT06749600