RecruitingNot ApplicableNCT06750497

Forearm Immobilization in T2D

The Impact of Short-term Forearm Immobilization on Forearm Muscle Glucose and Amino Acid Metabolism of Volunteers With or Without Type 2 Diabetes

Sponsor

Wageningen University

Enrollment

26 participants

Start Date

Nov 21, 2024

Study Type

INTERVENTIONAL

Conditions

Healthy Type 2 Diabetes

Summary

The aim of the present study is to assess the impact of short-term forearm immobilization on forearm muscle glucose uptake and amino acid net balance and kinetics in individuals with T2D compared with a control group with normoglycaemia.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Inclusion Criteria4

Males and females with or without diagnosed type 2 diabetes
Use lifestyle changes, metformin, gliclazide, or a combination thereof as oral glucose-lowering treatments for T2D
Aged 18-80 years at the time of signing informed consent
≥ BMI ≤ 35 kg·m2

Exclusion Criteria16

Type 1 or a genetic form of diabetes
Any diagnosed cardiovascular (heart) disease or high blood pressure (≥160 mmHg systolic and/or ≥100 mmHg diastolic)
Chronic use of any prescribed or over-the-counter pharmaceuticals (excluding oral contraceptives and contraceptive devices) that interact with muscle substrate metabolism (e.g. selective serotonin reuptake inhibitors)
Consumption of a low-carbohydrate diet
Smoking or chewing tobacco
Known anaemia
Regular use of dietary protein and/or amino acid supplements (\>3 times per week)
Currently involved in a structured progressive resistance training program (\>3 times per week)
A personal or family history of thrombosis (clots)
Any previous motor disorders or inborn errors in muscle and/or lipid metabolism
History of kidney disease
History of liver disease
Pregnant or breastfeeding
History of any drug or alcohol abuse in the past two years
Claustrophobia
Unable to give consent