Type 2 Diabetes Clinical Trials

401 recruitingLast updated: May 5, 2026

Type 2 Diabetes Trials at a Glance

500 actively recruiting trials for type 2 diabetes are listed on ClinicalTrialsFinder across 6 cities in 63 countries. The largest study group is Not Applicable with 228 trials, with the heaviest enrollment activity in San Antonio, Dallas, and Houston. Lead sponsors running type 2 diabetes studies include The University of Texas Health Science Center at San Antonio, Eli Lilly and Company, and Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd..

Browse type 2 diabetes trials by phase

Treatments under study

Understanding Type 2 Diabetes Clinical Trials

Semaglutide (Ozempic, Wegovy), which emerged from clinical trials as a GLP-1 receptor agonist, has not only improved blood sugar control but also demonstrated significant cardiovascular and weight-loss benefits that have reshaped how type 2 diabetes is managed. SGLT2 inhibitors like empagliflozin (Jardiance), also validated through landmark trials, have proven to protect the heart and kidneys in addition to lowering glucose. Clinical trials continue to push the boundaries of diabetes care, testing next-generation therapies that aim to achieve remission, protect organs, and reduce the daily burden of managing this chronic condition.

Why Consider a Clinical Trial?

Despite significant progress, many people with type 2 diabetes still struggle to achieve and maintain optimal blood sugar control, and complications affecting the heart, kidneys, eyes, and nerves remain common. Clinical trials offer access to next-generation GLP-1 and dual GIP/GLP-1 agonists, oral insulin formulations, cell-based therapies, and precision medicine approaches that could provide better results with fewer side effects than current treatments. Trials are also studying whether aggressive early treatment can put type 2 diabetes into sustained remission — meaning normal blood sugar levels without medication. For patients at high risk of developing diabetes, prevention trials test whether medications, dietary interventions, or digital health tools can stop or delay the disease from ever developing. Participation typically includes comprehensive metabolic monitoring that goes well beyond routine diabetes care.

Frequently Asked Questions

Common questions about Type 2 Diabetes clinical trials

It depends on the trial. Some studies allow you to continue your current medications and add the investigational treatment on top. Others may require you to stop or adjust certain medications to accurately assess the new therapy's effect. The study team will explain medication requirements during screening and ensure any changes are made safely.

The investigational treatment and research-related tests are typically covered by the trial sponsor at no cost to you. Routine care costs are usually billed to your insurance. Some trials offer stipends or reimbursement for travel and parking. Ask the study coordinator about financial details before enrolling.

Visit frequency varies by trial but is commonly every 4 to 12 weeks during active treatment. Some visits involve blood draws and physical exams, while others may be shorter check-ins. Many modern diabetes trials incorporate telehealth options to reduce the number of in-person visits required.

Many diabetes trials accept participants with common comorbidities, and some specifically study diabetes treatments in patients with cardiovascular or kidney disease. However, each trial has its own eligibility criteria. Having additional health conditions does not automatically disqualify you, and some trials are designed specifically for these populations.

When the trial ends, your study team will work with your regular doctor to transition you back to standard care. If the investigational treatment was effective, you may be eligible for an extension study that provides continued access. Your study team will ensure you have an appropriate treatment plan in place before discharge.

Showing 120 of 500 trials

Recruiting
Phase 4

Effect of Early Combination Antihyperglycemic Treatment on Metabolic Control in Individuals With Type 2 Diabetes

Type 2 Diabetes Mellitus (T2DM)
University Medical Centre Ljubljana90 enrolled1 locationNCT06613854
Recruiting

POLUS: Description of the Effectiveness and Tolerability of Luseogliflozin in Patients With Type 2 Diabetes.

Type 2 Diabetes Mellitus
Servier Russia300 enrolled1 locationNCT07433192
Recruiting

Manganese-enhanced Magnetic Resonance Imaging (MEMRI) in Heart Failure With Preserved Ejection Fraction

Type 2 DiabetesHeart Failure With Preserved Ejection Fraction
University of Leicester60 enrolled1 locationNCT06652763
Recruiting
Not Applicable

A U.S. Pilot Human Investigation of RadiofrEquency Vapor Ablation System to Evaluate Safety, TOleRability, and Effectiveness for Proximal Intestinal Mucosal Ablation in Patients With Type 2 Diabetes Mellitus (RESTORE-1 Study)

Type 2 Diabetes Mellitus
Aqua Medical, Inc.20 enrolled4 locationsNCT07355270
Recruiting
Not Applicable

The SWITCH (Substitution of High With Low Ultra-processed Soy Protein Foods In a Guideline-based Diet inTervention for Cardiometabolic Health) Trial

Metabolic HealthHypertensionDiabetes Mellitus, Type 2+3 more
University of Toronto300 enrolled1 locationNCT06907862
Recruiting
Not Applicable

The Treatment of Painful Diabetic Neuropathy With Diet

Peripheral Neuropathy With Type 2 DiabetesPainful Diabetic Neuropathy (PDN)Vegan Diet
AdventHealth40 enrolled1 locationNCT07509671
Recruiting
Phase 4

Effect of GLP-1RA on Cardiac Autonomic Neuropathy in Type 2 Diabetes

Type 2 DiabetesDiabetes With Diabetic Autonomic Neuropathy (Diagnosis)
The First Affiliated Hospital with Nanjing Medical University60 enrolled1 locationNCT07558863
Recruiting
Not Applicable

Exercise and Protein Efficiency in T2D

Type 2 DiabetesControl Condition
University of Illinois at Urbana-Champaign30 enrolled1 locationNCT07477067
Recruiting
Not Applicable

Virtual Diabetes Care for Adults With Type 2 Diabetes on Medicaid and Insulin Therapy

Type 2 Diabetes
Rutgers, The State University of New Jersey60 enrolled2 locationsNCT06814184
Recruiting
Not Applicable

Periodic Continuous Glucose Monitoring in Patients With Type 2 Diabetes

Type 2 Diabetes
Sophiahemmet University400 enrolled1 locationNCT05633628
Recruiting

Prevalence, Incidence and Risk Signature of Chronic Kidney Disease in Sub-Saharan Africa

ObesityCardiovascular DiseasesChronic Kidney Diseases+8 more
Swiss Tropical & Public Health Institute1,200 enrolled1 locationNCT05881447
Recruiting
Not Applicable

Pilot-Testing Strategies to Improve Outcomes for Youth With Type 2 Diabetes by Addressing Health-Related Social Needs

Type 2 DiabetesDiabetes in AdolescenceSocial Needs
University of Pittsburgh104 enrolled1 locationNCT07216118
Recruiting
Not Applicable

Culturally Tailored Program for Food-Insecure Adults: SPICE-D

Type 2 Diabetes Mellitus (T2D)
Wake Forest University Health Sciences25 enrolled1 locationNCT07361341
Recruiting

Optimization and Evaluation of the Diagnosis and Treatment System for Diabetic Retinopathy in Type 2 Diabetes Mellitus

DiabetesType 2 Diabetes Mellitus (T2DM)Diabetic Retinopathy
Yufan Wang2,920 enrolled3 locationsNCT06821399
Recruiting
Phase 3

A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes

Obesity or OverweightType 2 Diabetes Mellitus
Hoffmann-La Roche1,600 enrolled36 locationsNCT07351058
Recruiting
Phase 2

HP-211 Safety and Proof of Concept Dose Ranging Study in Patients With Type 2 Diabetes

Type 2 Diabetes
Housey Healthcare ULC300 enrolled25 locationsNCT07546929
Recruiting
Phase 2

Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)

Type 2 DiabetesCortisol Excess
Sparrow Pharmaceuticals1,500 enrolled47 locationsNCT07296484
Recruiting

Pharmacist-led Continuous Glucose Monitoring

Type 2 Diabetes
University of South Florida40 enrolled1 locationNCT06572306
Recruiting
Phase 3

A Study of Dulaglutide (LY2189265) 3.0 mg and 4.5 mg in Pediatric Participants With Type 2 Diabetes Mellitus (AWARD-PEDS PLUS)

Type 2 Diabetes
Eli Lilly and Company55 enrolled51 locationsNCT06739122
Recruiting
Phase 3

A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)

ObesityOverweightType 2 Diabetes+2 more
Pfizer999 enrolled184 locationsNCT07400653