Type 2 Diabetes Clinical Trials

536 recruitingLast updated: June 20, 2026

There are 536 actively recruiting type 2 diabetes clinical trials across 65 countries. Studies span Not Applicable, Phase 1, Phase 4, Phase 3, Phase 2, Early Phase 1. Top locations include San Antonio, Texas, United States, Houston, Texas, United States, Dallas, Texas, United States. Updated daily from ClinicalTrials.gov.


Type 2 Diabetes Trials at a Glance

536 actively recruiting trials for type 2 diabetes are listed on ClinicalTrialsFinder across 6 cities in 65 countries. The largest study group is Not Applicable with 245 trials, with the heaviest enrollment activity in San Antonio, Houston, and Dallas. Lead sponsors running type 2 diabetes studies include The University of Texas Health Science Center at San Antonio, Eli Lilly and Company, and The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School.

Browse type 2 diabetes trials by phase

Treatments under study

Understanding Type 2 Diabetes Clinical Trials

Semaglutide (Ozempic, Wegovy), which emerged from clinical trials as a GLP-1 receptor agonist, has not only improved blood sugar control but also demonstrated significant cardiovascular and weight-loss benefits that have reshaped how type 2 diabetes is managed. SGLT2 inhibitors like empagliflozin (Jardiance), also validated through landmark trials, have proven to protect the heart and kidneys in addition to lowering glucose. Clinical trials continue to push the boundaries of diabetes care, testing next-generation therapies that aim to achieve remission, protect organs, and reduce the daily burden of managing this chronic condition.

Why Consider a Clinical Trial?

Despite significant progress, many people with type 2 diabetes still struggle to achieve and maintain optimal blood sugar control, and complications affecting the heart, kidneys, eyes, and nerves remain common. Clinical trials offer access to next-generation GLP-1 and dual GIP/GLP-1 agonists, oral insulin formulations, cell-based therapies, and precision medicine approaches that could provide better results with fewer side effects than current treatments. Trials are also studying whether aggressive early treatment can put type 2 diabetes into sustained remission — meaning normal blood sugar levels without medication. For patients at high risk of developing diabetes, prevention trials test whether medications, dietary interventions, or digital health tools can stop or delay the disease from ever developing. Participation typically includes comprehensive metabolic monitoring that goes well beyond routine diabetes care.

Frequently Asked Questions

Common questions about Type 2 Diabetes clinical trials

It depends on the trial. Some studies allow you to continue your current medications and add the investigational treatment on top. Others may require you to stop or adjust certain medications to accurately assess the new therapy's effect. The study team will explain medication requirements during screening and ensure any changes are made safely.

The investigational treatment and research-related tests are typically covered by the trial sponsor at no cost to you. Routine care costs are usually billed to your insurance. Some trials offer stipends or reimbursement for travel and parking. Ask the study coordinator about financial details before enrolling.

Visit frequency varies by trial but is commonly every 4 to 12 weeks during active treatment. Some visits involve blood draws and physical exams, while others may be shorter check-ins. Many modern diabetes trials incorporate telehealth options to reduce the number of in-person visits required.

Many diabetes trials accept participants with common comorbidities, and some specifically study diabetes treatments in patients with cardiovascular or kidney disease. However, each trial has its own eligibility criteria. Having additional health conditions does not automatically disqualify you, and some trials are designed specifically for these populations.

When the trial ends, your study team will work with your regular doctor to transition you back to standard care. If the investigational treatment was effective, you may be eligible for an extension study that provides continued access. Your study team will ensure you have an appropriate treatment plan in place before discharge.

Showing 120 of 536 trials

Recruiting
Phase 3

A Study of Dulaglutide (LY2189265) 3.0 mg and 4.5 mg in Pediatric Participants With Type 2 Diabetes Mellitus (AWARD-PEDS PLUS)

Type 2 Diabetes
Eli Lilly and Company55 enrolled51 locationsNCT06739122
Recruiting

An Observational Study Called FINEROD to Learn More About the Use of the Treatment Finerenone Including How Safe it is and How Well it Works Under Real-world Conditions

Chronic Kidney DiseaseType 2 Diabetes Mellitus
Bayer50,000 enrolled4 locationsNCT06278207
Recruiting
Not Applicable

Pancreas Lipotoxicity in T2D: Edinburgh Diabetes Remission Study (EDRS)

Type 2 Diabetes
University of Edinburgh104 enrolled1 locationNCT07364045
Recruiting
Not Applicable

The Cognitive Protective Effect of VR-based Cognitive Training in Type 2 Diabetes Patients With Mild Cognitive Impairment

Type 2 Diabetes Mellitus (T2DM)Mild Cognitive Impairment (MCI)
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School40 enrolled1 locationNCT07650318
Recruiting
Phase 2

Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)

Type 2 DiabetesCortisol Excess
Sparrow Pharmaceuticals1,500 enrolled60 locationsNCT07296484
Recruiting
Not Applicable

Implementation pRogram to Improve Screening and Management for CKD in Diabetes (Program 1) (IRIS-CKD)

Type 2 Diabetes Mellitus (T2DM)Chronic Kidney Disease(CKD)Type 2 DM
Duke University750 enrolled7 locationsNCT06906627
Recruiting
Not Applicable

Implementation pRogram to Improve Screening and Management for CKD in Diabetes (IRIS-CKD) (Program 2)

Type 2 Diabetes Mellitus (T2DM)Chronic Kidney Disease(CKD)Type 2 DM
Duke University420 enrolled7 locationsNCT06906640
Recruiting
Not Applicable

Anti-inflammatory Dietary Intervention in Patients With Type 2 Diabetes: A Randomized Controlled Trial

T2DM (Type 2 Diabetes Mellitus)
Anhui Medical University88 enrolled1 locationNCT07656805
Recruiting

Mathematical Modeling of Blood Sugar and Hormone Responses in Insulin-Dependent Type 2 Diabetes

Type 2 DiabetesInsulin Dependent Diabetes
Clinical Nutrition Research Center, Illinois Institute of Technology25 enrolled1 locationNCT07650682
Recruiting
Not Applicable

Clinical Study to Evaluate the Impact of the Accu-Chek SmartGuide CGM Solution on the Mean Change in Time in Range Compared With Self-Monitoring of Blood Glucose in Participants With Type 1 and Type 2 Diabetes Mellitus

Type 1 Diabetes MellitusType 2 Diabetes Mellitus
Hoffmann-La Roche270 enrolled18 locationsNCT06704672
Recruiting

An Observational Study Called FINE-REAL Korea to Learn More About the Use of the Drug Finerenone in People With Chronic Kidney Disease and Type 2 Diabetes in a Routine Medical Care Setting in South Korea

Chronic Kidney DiseaseType 2 Diabetes Mellitus
Bayer500 enrolled1 locationNCT07232537
Recruiting
Not Applicable

DASH-Obesity: Explainable AI for Family-Centric Personalized Weight Control in Adolescents and Young Adults With Obesity and Chronic Conditions

Obesity, OverweightAsthma (Diagnosis)Type 1 Diabetes+3 more
Adhera Health, Inc.280 enrolled1 locationNCT07638345
Recruiting
Phase 2

Phase 2 Trial of Icovamenib in Participants With Type 2 Diabetes Mellitus Who Are Not Achieving Glycemic Targets While Using GLP-1-Based Therapy

Type 2 Diabetes
Biomea Fusion Inc.60 enrolled17 locationsNCT07502508
Recruiting

Validity and Reliability of Mixed Reality-Based Functional Mobility Tests in Type 2 Diabetes

Type 2 Diabetes Mellitus (T2DM)
Selcuk University75 enrolled1 locationNCT07649967
Recruiting
Phase 1

THC Effects on Glucose in Type 2 Diabetes

Type 2 Diabetes
University of California, San Diego30 enrolled1 locationNCT05322213
Recruiting

Measurements Before and After Participation in a Health Intervention Programme in Halsnaes Municipality

Chronic Obstructive Pulmonary Disease (COPD)Cardiovascular DiseaseType 2 Diabetes
Steno Diabetes Center Copenhagen194 enrolled1 locationNCT07641309
Recruiting
Not Applicable

Primary Care Pragmatic, Real World Experience for Automated Insulin Delivery

Diabetes MellitusDiabetes Mellitus, Type 2Diabetes+8 more
University of Colorado, Denver240 enrolled2 locationsNCT07011147
Recruiting
Phase 1Phase 2

A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM

Type 2 Diabetes Mellitus (T2DM)Obese or Overweight Healthy Volunteers
Alnylam Pharmaceuticals144 enrolled22 locationsNCT06845202
Recruiting
Phase 2

A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus (T2DM)
Alnylam Pharmaceuticals40 enrolled1 locationNCT07465224
Recruiting
Not Applicable

Impact of Pilates Exercises on Diabetic Erectile Dysfunction.

Pilates ExerciseDiabete MellitusErectile Dysfunction Associated With Type 2 Diabetes Mellitus+1 more
Benha University60 enrolled2 locationsNCT07293156