RecruitingPhase 1Phase 2NCT06754930

A Study of SHR-1826 for Injection in Combination With Other Antitumor Therapies in Subjects With NSCLC

A Multicenter, Open Phase IB/II Clinical Study of Safety, Tolerability, and Efficacy of SHR-1826 in Combination With Other Anti-cancer Treatment in Patients With Non-small Cell Lung Cancer


Sponsor

Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Enrollment

400 participants

Start Date

Feb 18, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This is an open label, multi-center, multiple dose Phase IB/II study to evaluate the safety, tolerability and efficacy of SHR-1826 for injection in subjects with NSCLC.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study tests SHR-1826 — a new investigational drug — either alone or in combination with other cancer treatments in people with non-small cell lung cancer (NSCLC), to assess its safety and effectiveness. **You may be eligible if...** - You are 18–75 years old with a confirmed diagnosis of NSCLC - You are in good health (ECOG 0–1) with at least 3 months expected survival - You have at least one measurable tumor - Your organ function (liver, kidney, blood) is adequate - You are willing to provide a tumor tissue sample **You may NOT be eligible if...** - Your cancer has spread to the brain lining (meningeal metastasis) - You have had another cancer or are currently being treated for one - You have active hepatitis B or C - You have a history of immune deficiency - You had major surgery within 28 days before starting treatment - You have uncontrolled severe cardiovascular disease - You had a severe infection within 30 days before the first dose Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSHR-1826

SHR-1826 for injection.

DRUGSHR-1316

SHR-1316 for injection.

DRUGSHR-9839

SHR-9839 for injection.

DRUGSHR-8068

SHR-8068 for injection.

DRUGAmetinib mesylate

Ametinib mesylate.

DRUGBP-102

BP-102 for injection.

DRUGCarboplatin

Carboplatin for injection.


Locations(1)

Shanghai Chest Hospital

Shanghai, Shanghai Municipality, China

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NCT06754930


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