RecruitingNCT06756009

Evaluation of Chronic Liver Disease Condition and Transplant Prognosis Assisted by Eye Biological Parameters

Sponsor

Zhongshan Ophthalmic Center, Sun Yat-sen University

Enrollment

500 participants

Start Date

Mar 1, 2022

Study Type

OBSERVATIONAL

Conditions

Liver Transplantation Liver Cirrhoses Diagnostic Techniques, Ophthalmological

Summary

This study investigates the correlation between ocular biological characteristics and overall conditions before and after liver transplantation by collecting ocular biological characteristics. Explore whether it is possible to construct a clinical prediction model for liver transplantation by incorporating ocular biometric features, in order to optimize disease management before and after liver transplantation.

Eligibility

Min Age: 18 Years

Inclusion Criteria5

Age greater than or equal to 18 years old;
Late stage liver disease patients waiting for liver transplantation treatment, as well as patients with varying degrees of cirrhosis;
Can collect complete basic demographic information, liver function blood test indicators, liver pathology and imaging examination results;
Can cooperate with eye OCT, OCTA and other examinations, and obtain qualified examination parameters;
Voluntarily follow the clinical trial protocol and sign the informed consent form.

Exclusion Criteria5

History of other organ transplant surgeries;
History of intraocular laser treatment, medication injection, and surgery;
History of high myopia, glaucoma, and retinal choroidal related eye diseases;
History of major systemic diseases other than liver disease;
Individuals whose overall body and eye conditions cannot cooperate with eye examinations.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DIAGNOSTIC_TESTOphthalmic examination

Various ophthalmic examination modalities, including slit lamp photography, fundus photography, optical coherence tomography imaging and optical coherence tomography angiography, etc.

DIAGNOSTIC_TESTGeneral Condition Examination

Various general condition examination, including blood pressure measurement, blood glucose testing, blood routine examination, coagulation function test, liver function test, etc.