RecruitingEarly Phase 1NCT06756334

Head-to-head Comparison of [18F]AlF-PSMA-N5 With [18F]F-DCFPyL PET/CT in PCa Diagnosis, Recurrence, and Metastasis

Head-to-head Comparison of [18F]AlF-PSMA-N5 With [18F]F-DCFPyL PET/CT in Prostate Cancer Diagnosis, Recurrence, and Metastasis: a Prospective Study


Sponsor

Anhui Provincial Hospital

Enrollment

30 participants

Start Date

Dec 19, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

To prospectively evaluate the radiodrug biodistribution of a novel PET imaging agent \[18F\]AlF-PSMA-N5 in different organs of prostate cancer patients and its diagnostic efficacy in the diagnosis, recurrence and metastasis of prostate cancer, and to compare with \[18F\]F-DCFPyL.


Eligibility

Sex: MALEMin Age: 18 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two types of PSMA PET scans — a way to detect prostate cancer by imaging specific proteins on cancer cells — to see which is more accurate for diagnosing prostate cancer, detecting recurrence after treatment, and finding spread to other areas. **You may be eligible if...** - You are between 18 and 90 years old - You have been diagnosed or are suspected of having prostate cancer (by PSA blood test or imaging) - You have complete MRI images and clinical data available - You are willing to have both scan types done within two weeks of each other - You agree to have a biopsy or surgery for tissue confirmation **You may NOT be eligible if...** - You are unable to cooperate with the scanning process - You have another active cancer - You have a known allergy to alcohol (used in the scan preparation) - You have significant liver or kidney problems Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUG[18F]AlF-PSMA-N5

Each subject receive a single intravenous injection of \[18F\]AlF-PSMA-N5, and undergo PET/CT imaging within the specificed time.

DRUG[18F]F-DCFPyL

Each subject receive a single intravenous injection of \[18F\]F-DCFPyL, and undergo PET/CT imaging within the specificed time.


Locations(1)

The First Affiliated Hospital of China University of Science and Technology(Anhui Provincial Hospital)

Hefei, Anhui, China

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NCT06756334


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