Allopregnanolone (Zuranolone) in Post-stroke Depression

This study is testing whether zuranolone (also called allopregnanolone), a medication that rapidly eases depression by acting on a calming receptor in the brain, can treat moderate to severe depression that develops after a stroke (called post-stroke depression). **You may be eligible if...** - You are between 21 and 65 years old - You had a stroke (confirmed by brain imaging) within the past year - You have moderate to severe depression that has lasted at least 2 weeks (score of 17 or more on the Hamilton Depression scale) **You may NOT be eligible if...** - You have a history of narcotic, recreational drug, or alcohol abuse or dependence - You have severe liver or kidney disease - You are pregnant, breastfeeding, or postpartum - You have a history of attempted suicide or active suicidal thoughts - You have bipolar disorder, schizophrenia, or treatment-resistant depression that predated the stroke - You recently started or changed antidepressants (within 12 weeks) Talk to your doctor to see if this trial is right for you.