RecruitingNCT06769347

Circulating Vascular Regenerative Cell Exhaustion in Individuals Without Type 2 Diabetes Who Are of South Asian or European Origins


Sponsor

Canadian Medical and Surgical Knowledge Translation Research Group

Enrollment

120 participants

Start Date

Jan 30, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

ORIGINS-VRCE-2 is an observational study aimed to assess how blood vessel forming stem cells from individuals without diabetes or a history of cardiovascular disease differ between individuals of South Asian and European ethnicities. The overarching objective of the study is to investigate whether differential vessel reparative stem cell populations and characteristics may underlie the elevated cardiovascular risk observed among South Asian individuals compared to individuals of European origins.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing the health of blood vessel repair cells in people of South Asian origin versus European origin who do not have type 2 diabetes. The goal is to understand whether South Asians — who are known to have higher rates of cardiovascular disease — show early signs of vascular cell exhaustion even before diabetes develops. **You may be eligible if...** - You are 18 or older - You identify as being of South Asian origin (including Indian, Pakistani, Bangladeshi, Sri Lankan, and other South Asian backgrounds) OR of European origin - You do not have type 2 diabetes - You are willing and able to provide informed consent and follow the study procedures **You may NOT be eligible if...** - You have been diagnosed with type 2 diabetes - You do not meet other screening criteria (such as having certain health conditions that could affect vascular cell health) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(5)

Markham HealthPlex Medical Centre

Markham, Ontario, Canada

North York Diagnostic and Cardiac Centre

North York, Ontario, Canada

Marlee Medical Centre

North York, Ontario, Canada

Diagnostic Assessment Centre

Scarborough Village, Ontario, Canada

Langstaff Medical Centre

Woodbridge, Ontario, Canada

View Full Details on ClinicalTrials.gov

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NCT06769347