RecruitingNot ApplicableNCT06769464

Electrophysiological Representations of Odor in the Human Brain Study 1


Sponsor

Northwestern University

Enrollment

28 participants

Start Date

Apr 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Investigating representations of odor intensity in human piriform cortex. To identify a neural representation of perceived odor intensity, it is necessary to dissociate stimulus concentration from perceived intensity. Experiments for this aim will measure human perceptual responses while manipulating intensity independently from concentration using two complementary approaches. In Experiment 1A, we will match perceived intensities across odors of different concentrations, allowing us to identify a neural representation of intensity that is independent of stimulus identity and concentration. In Experiment 1B, we will create conditions of different perceived intensity over constant odor stimuli using adaptation. Approaching the same question from different angles will strengthen the robustness of our findings. Preliminary data suggest that temporal features of the piriform neural response may represent odor intensity.


Eligibility

Min Age: 12 YearsMax Age: 65 Years

Inclusion Criteria1

  • Ages 12 to 65, english speaker, patients undergoing brain surgery for treatment of medically intractable epilepsy

Exclusion Criteria1

  • screening for history of smell or taste problems

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Interventions

BEHAVIORALodor

present odor


Locations(1)

Northwestern University

Chicago, Illinois, United States

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NCT06769464