RecruitingNCT06771960

Association Between RVT and Prognosis After Neoadjuvant Targeted Therapy in EGFR NSCLC

Association Between Residual Viable Tumor and Prognosis After Neoadjuvant Targeted Therapy in EGFR-Mutated Non-small Cell Lung Cancer


Sponsor

Guangdong Provincial People's Hospital

Enrollment

120 participants

Start Date

Feb 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

EGFR-mutated NSCLC is a distinct subtype that responds well to targeted therapies. Neoadjuvant targeted therapy aims to downstage tumors and improve surgical outcomes, but the prognostic role of residual viable tumor (RVT) remains unclear. This retrospective study examines the association between RVT and survival outcomes. The findings will further validate the importance of RVT as a surrogate.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This is an observational study examining whether a measurement called residual volume tumor (RVT) — the amount of cancer remaining after targeted therapy before surgery — can predict long-term outcomes for people with non-small cell lung cancer (NSCLC) that has a specific gene mutation called EGFR. It aims to identify who responds best to pre-surgical drug treatment. **You may be eligible if...** - You are 18–80 years old - You have EGFR-mutated non-small cell lung cancer confirmed by pathology - You received neoadjuvant (pre-surgery) targeted therapy - You underwent definitive surgery for your lung cancer **You may NOT be eligible if...** - You have a history of prior chemotherapy, immunotherapy, or radiotherapy for this cancer - You have a history of another cancer or prior lung surgery - Key data needed for the study is missing from your records Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Guangdong Provincial People's Hospital

Guangzhou, Guangdong, China

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NCT06771960


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