Building Evidence for Ablative Internal Radiation Therapy in Localized HCC Beyond the Up-To-7 Criteria

This study is testing a type of internal radiation treatment (called ablative radioembolization) for people with liver cancer (hepatocellular carcinoma, or HCC) that has grown too large or involves too many tumors for standard surgery or local treatments. The treatment delivers radiation beads directly into the liver's blood vessels to target the tumors. **You may be eligible if...** - You are 19 years or older - You have liver cancer confirmed by biopsy or imaging - Your cancer is in the liver only (not spread outside) and affects between 1 and 5 neighboring liver sections - Your liver function is relatively good (Child-Pugh class A) - You are generally active and able to care for yourself (ECOG score 0–1) - Enough healthy liver tissue would remain after treatment **You may NOT be eligible if...** - Your cancer has spread outside the liver - Your liver function is significantly impaired - You have previously had HCC in the part of the liver that would remain after treatment - Your blood counts or organ function do not meet the required levels Talk to your doctor to see if this trial is right for you.