Endometrioma Sclerotherapy and Ovarian Preservation
Endometrioma Sclerotherapy and Ovarian Preservation: a Randomised Control Trial of Laparoscopic Sclerotherapy vs Traditional Excision of Endometrioma
Chelsea and Westminster NHS Foundation Trust
60 participants
Feb 21, 2025
INTERVENTIONAL
Conditions
Summary
A randomised controlled trial assessing ovarian reserve after laparoscopic ethanol sclerotherapy of ovarian endometrioma compared to standard treatment of surgical excision of endometrioma. Secondary outcomes will include endometrioma recurrence, symptomatology and inflammatory environment.
Eligibility
Inclusion Criteria4
- Female (XX genotype, assigned female at birth)
- Age 18-40
- Finding of suspected uni- or bi-lateral ovarian endometrioma(ta) of ≥ 2cm on TVUSS and/or pelvic MRI scan (TVUSS, a uni- or multi-locular ovarian cystic lesion with low level echoes and diffuse homogeneous ground glass appearance; MRI any of, ovarian lesion hyperintense T1 without loss of signal on T1 fat-suppressed images, hypointense T2 exhibiting shading sign and/or T2 dark spot sign, variable restricted diffusion on DWI)
- Appropriate to be listed for laparoscopic excision of endometrioma (Endometrioma ≥2cm, pain symptoms attributable to endometriosis where medical management is unsuccessful or unacceptable to the patient, to facilitate ART)
Exclusion Criteria7
- Postmenopausal status
- Suspicion of malignancy
- Unable to undergo TVUSS
- Declines to take part in the study
- Unable to understand verbal or written information in English
- Lack of capacity to consent at the point of recruitment
- Known safeguarding issues
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Laparoscopic ethanol sclerotherapy of endometrioma
Routine surgical management of endometrioma
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06775769