RecruitingNot ApplicableNCT06776224

Visual (Path)Ways in Multiple Sclerosis - Part II

Evaluation of Neuroaxonal Loss Outside of Any Inflammation in Multiple Sclerosis by a Multimodal Study of the Visual Pathways Model

Sponsor

University Hospital, Lille

Enrollment

64 participants

Start Date

Jan 24, 2025

Study Type

INTERVENTIONAL

Conditions

Multiple Sclerosis, Optic Neuritis, Demyelinating Disease

Summary

Multiple sclerosis (MS) is an inflammatory demyelinating and degenerative disease of the central nervous system. The mechanisms of neuro-axonal loss remain incompletely elucidated. An acute demyelinating lesion will produce both immediate and delayed axonal loss. Immediate axonal loss is linked to the occurrence of axonal transection. Delayed axonal loss is the cause of axonal degeneration in progressive MS. Visual impairment is common in the disease (vision, oculomotricity, cognition). Through a longitudinal multimodal analysis of visual pathways, we would like to investigate physiopathological mechanisms leading to neurodegenerative process and visual impairment.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is a follow-up of a previous study (called VWIMS) tracking how vision and brain pathways change over time in people with relapsing-remitting multiple sclerosis (MS). MS is a condition where the immune system attacks the nerves, and this study uses MRI brain scans and eye scans to track these changes. **You may be eligible if...** - You participated in the original VWIMS study - You are 18 years or older - You have relapsing-remitting MS and are receiving treatment at the Lille University Hospital MS centre - You are willing to comply with study procedures and give written consent - You are covered by social insurance **You may NOT be eligible if...** - You have diabetes, retinal disease, glaucoma, retinal detachment, or very significant refractive eye problems - You have a condition that would interfere with MRI or eye scans - You cannot have an MRI (claustrophobia or incompatible implants) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERMeasurement of retinal vascular density and visual cognition

During the same visit, we will perform OCT-angiography (10 minutes) and evaluate visual cognition with an eye-tracker (20 minutes)

Locations(1)

Direction de la Recherche et de l'innovation (DRI) 6 rue Professeur Laguesse

Lille, France

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NCT06776224