RecruitingNCT06780826

A Study on the Efficacy of Atezolizumab Combined with Chemotherapy

A Simulated RCT Study on the Efficacy of Atezolizumab Combined with Chemotherapy Versus Placebo Combined with Chemotherapy in Small Cell Lung Cancer


Sponsor

Shanghai Pulmonary Hospital, Shanghai, China

Enrollment

1,430 participants

Start Date

Aug 28, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

This is a multicenter phase III simulated RCT study aimed to compare the efficacy and safety of atezolizumab combined with chemotherapy versus placebo combined with chemotherapy in small cell lung cancer.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether adding atezolizumab (an immunotherapy drug) to standard chemotherapy works better than chemotherapy alone for people with extensive-stage small cell lung cancer — a fast-growing form of lung cancer that has spread widely. **You may be eligible if...** - You are 18 or older - You have been diagnosed with extensive-stage small cell lung cancer - You have not yet received treatment for this diagnosis - You are in good general health (ECOG 0 or 1) - You have at least one measurable tumor on imaging **You may NOT be eligible if...** - You have already received treatment for small cell lung cancer - You have uncontrolled brain metastases requiring steroids - You have serious heart, liver, or kidney problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAtezolizumab

Atezolizumab, 1200 mg intravenous infusion, 21 days per cycle

DRUGEtoposide

Etoposide,intravenous infusion, 100mg/m,21 days per cycle

DRUGCarboplatin

carboplatin,intravenous infusion, AUC=5, 21 days per cycle.


Locations(1)

Shanghai Pulmonary Hospital

Shanghai, China

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NCT06780826


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