RecruitingPhase 1NCT06781983

Safety and Tolerability of IPH4502 in Patients With Advanced Solid Tumors

A Phase 1, Open-label, Multi-center Study of the Safety, Tolerability, and Efficacy of IPH4502 as a Single Agent in Advanced Solid Tumors


Sponsor

Innate Pharma

Enrollment

145 participants

Start Date

Jan 24, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This is a first-in-human, open-label, multicenter, Phase 1 study to evaluate the safety, tolerability and preliminary efficacy of IPH4502 and to determine the recommended Phase 2 dose (RP2D) in advanced solid tumors that are known to express Nectin-4


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This early-phase study is testing the safety of IPH4502, a new experimental drug, in people with advanced solid tumors that express a protein called Nectin-4. This includes cancers like bladder, lung, breast, and cervical cancer. The goal is to find a safe dose and understand how the body processes the drug. **You may be eligible if...** - You have advanced or metastatic solid cancer known to express Nectin-4 - You have received prior treatments but have no more standard options available - You have measurable disease on imaging - Your organ function is adequate **You may NOT be eligible if...** - You have known or suspected brain metastases - You have active or serious infections - You have interstitial lung disease - You are on systemic steroids or immune-suppressing drugs - You have had a recent blood clot requiring anticoagulation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGIPH4502

Part 1 (dose escalation) and Part 2 (dose optimization)


Locations(7)

Massachusetts General Hospital - Boston

Boston, Massachusetts, United States

John Theurer Cancer Center

Hackensack, New Jersey, United States

Mount Sinai Tisch Cancer Center

New York, New York, United States

NEXT Oncology - Dallas

Dallas, Texas, United States

NEXT Oncology - Virginia

Fairfax, Virginia, United States

Centre Léon Bérard

Lyon, France

Gustave Roussy Cancer Institute

Villejuif, France

View Full Details on ClinicalTrials.gov

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NCT06781983


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