RecruitingPhase 4NCT06782529

Knee Injections for Obese Patients With Knee Arthritis

Comparison of Varying Doses of Steroid for Intra-articular Knee Injections


Sponsor

Mayo Clinic

Enrollment

40 participants

Start Date

Jan 24, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to assess obese patients with knee arthritis and determine the non-inferiority of a low dose steroid treatment vs. standard dose steroid treatment for two knee outcome measures: pain and function.


Eligibility

Min Age: 55 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how well a lower dose of steroid injections works compared to the standard dose for people with knee arthritis who are obese (BMI of 30 or higher). Researchers want to find out if a reduced steroid dose can still effectively reduce pain and improve knee function. You may be eligible if you have X-ray-confirmed knee arthritis, a BMI of 30 or higher, and are interested in a steroid knee injection — though people with poorly controlled diabetes (HbA1c above 8%) or those currently in physical therapy are not eligible. Participation involves receiving a knee injection and being followed for pain and function outcomes over the study period. This summary was prepared with AI assistance to help patients understand the study in plain language.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGTriamcinolone Acetonide Low Dose

Subjects will receive a reduced dose of 20mg of triamcinolone acetonide. Total injection volume of 5ml, consisting of: * 0.5ml triamcinolone acetonide (20mg) * 4.5ml lidocaine (45mg)

DRUGTriamcinolone Acetonide Standard Dose

Subjects will receive the standard of care dose of 40mg triamcinolone acetonide Total injection volume of 5ml, consisting of: * 1ml triamcinolone acetonide (40mg) * 4ml lidocaine (40mg)


Locations(1)

Mayo Clinic in Florida

Jacksonville, Florida, United States

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NCT06782529


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