RNS for Treatment-resistant Obsessive-compulsive Disorder

This study is testing a brain stimulation technique called RNS (responsive neurostimulation) for people with severe, treatment-resistant obsessive-compulsive disorder (OCD). RNS detects abnormal brain activity and delivers a tiny corrective electrical pulse to the brain in real time. **You may be eligible if...** - You are between 18 and 65 years old - You have a confirmed diagnosis of OCD - You have tried at least two SSRIs (each for 3–6 months), high-dose clomipramine (3–6 months), cognitive behavioral therapy (6 months), and antipsychotic medications — none of which worked **You may NOT be eligible if...** - You have other psychotic disorders - You have previously had electroconvulsive therapy (ECT), deep brain stimulation (DBS), TMS, or tDCS - You are at significant risk of suicide Talk to your doctor to see if this trial is right for you.