RecruitingNCT06782971

Evaluation of Combined Sensitising and Hypomethylating Therapy Outcomes in AML PDX

COSMOS-Avatar: Evaluation of Combined Sensitising and Hypomethylating Therapy Outcomes in AML PDX

Sponsor

Clinical Hub for Interventional Research (CHOIR)

Enrollment

25 participants

Start Date

Jun 6, 2025

Study Type

OBSERVATIONAL

Summary

The goal of this observational study is to develop new ways to test new drug combinations to kill tumour cells, in patients with acute myeloid leukemia (AML). The main questions it aims to answer are: * Are there new ways to speed up discovery of better treatments for AML patients using AML cells from individual from patients in special mice that can accept human tissue? * Do these mice show treatment responses that are similar to the individual AML patient from whom cells were derived? Participants with AML who are taking standard of care treatment of venetoclax and azacitidine will be asked to donate blood and bone marrow samples for this study.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is following patients with acute myeloid leukemia (AML) — a fast-growing blood cancer — who are being treated with venetoclax plus azacitidine (a common combination) to observe real-world outcomes and how the treatment affects the cancer over time. No experimental drugs are being used; this is an observational study. **You may be eligible if...** - You are 18 or older - You have been diagnosed with AML (all subtypes) - You are about to start treatment with venetoclax and azacitidine - You have at least 20% blast cells (immature blood cells) in your bone marrow or blood **You may NOT be eligible if...** - Your doctor believes participation would compromise your safety or the quality of the study data Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(4)

Canberra Health Services

Canberra, Australian Capital Territory, Australia

Prince of Wales Hospital

Sydney, New South Wales, Australia

Royal North Shore Hospital

Sydney, New South Wales, Australia

Westmead Hospital

Westmead, New South Wales, Australia

View Full Details on ClinicalTrials.gov

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NCT06782971