Phase 1 Study of OP-3136 in Advanced or Metastatic Solid Tumors

This is a Phase 1 safety study of a new experimental drug called OP-3136 for people with advanced cancers that have spread and are no longer responding to standard treatments. The cancers being studied include hormone receptor-positive breast cancer, advanced prostate cancer, and non-small cell lung cancer. **You may be eligible if...** - You have advanced or metastatic ER-positive, HER2-negative breast cancer, prostate cancer (mCRPC), or non-small cell lung cancer - Your cancer is no longer responding to available treatments or those treatments are not tolerable - You are well enough to participate in a clinical trial **You may NOT be eligible if...** - You have a different type of cancer not listed above - Your cancer has not yet progressed on standard therapies - You have significant health conditions that prevent trial participation Talk to your doctor to see if this trial is right for you.