RecruitingNot ApplicableNCT06785324

Study of Nutrition and Exercise in Adults Hospitalized for Treatment of Acute Lymphoblastic Leukemia (ALL)

Nutrition and Exercise to Optimize Muscle and Adiposity in Adults With ALL: NEOMA ALL Trial

Sponsor

University of Chicago

Enrollment

20 participants

Start Date

May 12, 2025

Study Type

INTERVENTIONAL

Conditions

Philadelphia Chromosome Negative

Summary

This clinical trial aims to assess the effect of nutrition and exercise on muscle and adiposity in adults with Philadelphia Chromosome (Ph) Negative B-ALL undergoing inpatient induction therapy. Participants will take part in 2 different interventions: * Nutrition Intervention * Physical Exercise Intervention All subjects will be provided with a wearable electronic activity monitor (FitBit®) to assist in recording activity levels in minutes of activity.

Eligibility

Min Age: 18 YearsMax Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study is testing the effects of a structured nutrition and exercise program in adults who are hospitalized for treatment of acute lymphoblastic leukemia (ALL), a fast-growing blood cancer. Researchers want to see if nutrition support and physical activity during intensive chemotherapy can improve health outcomes. **You may be eligible if...** - You have been newly diagnosed with Philadelphia chromosome-negative B-cell ALL (a specific type of leukemia) - You are receiving intensive induction chemotherapy (first-round intensive treatment) **You may NOT be eligible if...** - Your BMI is 18.5 or below at the time of diagnosis (underweight) - You are pregnant - You are physically or mentally unable to follow the required diet and exercise program Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALNutrition Intervention

The nutrition intervention will target a 10% caloric deficit calculated from each patient's Basal Metabolic Rate (WHO/Schofield) utilizing a high protein (\>25%), low fat (\<25%), low glycemic index/high fiber (45-55%) diet. The study registered dietician (RD) will meet with the patient on day of enrollment to go over the "menu" of dietary options and will re-assess the patient every two days (excluding weekends) for adherence. My Plate (USDA) will control portion size and eating habits.

BEHAVIORALExercise intervention

The exercise intervention will target 200 minutes of "moderate" physical activity weekly, as defined by Metabolic Equivalents (METs) of 3-6, made up of aerobic and resistance training activities tailored to the patient's preference by working with the study physical therapist (PT). Physical Therapist to evaluate patient every 48 hours, excluding weekends.

Locations(1)

University of Chicago Medicine Comprehensive Cancer Center

Chicago, Illinois, United States

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NCT06785324