RecruitingNCT06786949

Night-shift Work and Breast Cancer

Sponsor

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Enrollment

6,000 participants

Start Date

Jan 31, 2025

Study Type

OBSERVATIONAL

Conditions

Breast Cancer Risk Factors

Summary

Scientific evidence established about the effects of night work on health both in the short term (insomnia, excessive sleepiness, difficulty concentrating or lack of energy) and in the long term (moderately high risk of developing cardiovascular disease, type 2 diabetes, depression, cancer). In light of the scientific evidence, the IARC (International Agency for Research on Cancer) has listed night work as a probable human carcinogen (Group 2). With respect to current knowledge, the present study could provide valuable help in understanding the mechanisms by which circadian rhythm alteration acts at the genetic level in terms of promoting oncogenesis. Furthermore, by studying its association with other risk factors, understand whether there is a pattern of women more susceptible to its oncopromoting action.

Eligibility

Sex: FEMALEMin Age: 20 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether working night shifts is associated with a higher risk of breast cancer in female healthcare workers. Researchers will review medical records from hospital staff in Italy to study the relationship between night-shift work and breast cancer diagnosis. **You may be eligible if...** - You are a female healthcare worker (doctor, nurse, or healthcare support staff) - You have worked at one of the participating Italian hospitals for at least 6 months between 2000 and 2021 - You were between 20 and 70 years old at the start of the follow-up period **You may NOT be eligible if...** - You have tested positive for BRCA1 or BRCA2 genetic mutations (which independently raise breast cancer risk) - You do not meet the employment or age criteria Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERQuestionnaire

All cases and controls will be contacted by telephone or e-mail and invited to participate in the study. Female workers who decide to join the study will be asked to go to their company's occupational health clinic where they will undergo administration of a questionnaire to investigate possible known and unknown risk factors for breast cancer

DIAGNOSTIC_TESTBlood samples for biomarker measurement

Women who give consent to undergo this phase of the study will be called back to the center and will be asked to provide a blood sample

Locations(2)

IRCCS Azienda Ospedaliero - Universitaria di Bologna, U.O. Medicina del Lavoro

Bologna, Italy

AOU G. Martino Messina U.O.S.D. Medicina del Lavoro

Messina, Italy

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NCT06786949