Night-shift Work and Breast Cancer
IRCCS Azienda Ospedaliero-Universitaria di Bologna
6,000 participants
Jan 31, 2025
OBSERVATIONAL
Conditions
Summary
Scientific evidence established about the effects of night work on health both in the short term (insomnia, excessive sleepiness, difficulty concentrating or lack of energy) and in the long term (moderately high risk of developing cardiovascular disease, type 2 diabetes, depression, cancer). In light of the scientific evidence, the IARC (International Agency for Research on Cancer) has listed night work as a probable human carcinogen (Group 2). With respect to current knowledge, the present study could provide valuable help in understanding the mechanisms by which circadian rhythm alteration acts at the genetic level in terms of promoting oncogenesis. Furthermore, by studying its association with other risk factors, understand whether there is a pattern of women more susceptible to its oncopromoting action.
Eligibility
Inclusion Criteria4
- Health workers with any type of contract and qualification (doctors, nurses, OSS) in service at IRCSS AOUBO and AOU "G. Martino" of Messina for at least six months between 1.1.2000 and 31.12.2021
- Age between 20 and 70 years at the start of study follow-up (6 months after recruitment or 1.1.2000)
- Female gender
- For secondary objective 2 of the study only, women exposed to night work must have worked at least 6 night shifts per month in the past six months
Exclusion Criteria2
- Women found to be positive for BRCA1 and BRCA2 genetic mutation (BRCA1 and 2 mutations are searched for by geneticists in sick women for whom there is a consistent suspicion of mutation)
- Women with prior history of breast cancer at the time of recruitment or within six months thereafter.
Interventions
All cases and controls will be contacted by telephone or e-mail and invited to participate in the study. Female workers who decide to join the study will be asked to go to their company's occupational health clinic where they will undergo administration of a questionnaire to investigate possible known and unknown risk factors for breast cancer
Women who give consent to undergo this phase of the study will be called back to the center and will be asked to provide a blood sample
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06786949