RecruitingNot ApplicableNCT06787937

Communicating About Nicotine Reduction in Cigarettes

Communicating About Nicotine and Differential Risks of Tobacco Products in Priority Populations


Sponsor

Georgia State University

Enrollment

1,230 participants

Start Date

Sep 11, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn how a messaging campaign about reduced nicotine cigarettes and policy, combined with the use of very low nicotine cigarettes (VLNCs), affects smoking behavior and attitudes among adult smokers. The study also aims to assess the efficacy of the messages in different populations, including smokers with past-month serious psychological distress (SPD), low socioeconomic status (SES), and those in neither category. The primary hypothesis is: exposure to messages in combination with VLNC use will lead to less cigarettes use compared to VLNCs without messages. Researchers will compare: The effects of receiving VLNCs with messages (treatment group) to receiving VLNCs without messages (control group). Participants will: Complete a baseline survey and be randomly assigned to one of two groups: treatment (VLNCs + messages) or control (VLNCs only). Attend weekly study visits for surveys, breath samples, and receive supply of VLNCs , either with or without the messaging campaign. Complete brief daily surveys through text messages.


Eligibility

Min Age: 21 Years

Inclusion Criteria5

  • Age 21+ years
  • Current smoker (self-report as having smoked 100 cigarettes in their lifetime and currently smoking on 27+ days out of past 30, expired breath carbon monoxide \[CO\] ≥6ppm to assess regular smoking)
  • Can speak, read, and write in English
  • Available for period of study
  • Willing to try novel research cigarettes

Exclusion Criteria3

  • Pregnancy or lactation
  • Member of the same household as a study subject
  • Unwilling to use research cigarettes as part of the trial

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Interventions

BEHAVIORALVLNC messages

Participants will be exposed to messaging about VLNCs and reduced nicotine policy through multiple formats, including inserts placed in cigarette packs, printed advertisements, and video materials presented during their weekly visits.

BEHAVIORALControl message

Participants will be exposed to control messages, such as advertisements for bottled water, during their weekly visits.


Locations(2)

Georgia State university

Atlanta, Georgia, United States

Emory University

Atlanta, Georgia, United States

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NCT06787937


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