RecruitingEarly Phase 1NCT06791681

A Study of ESO-T01 in Treating Relapsed/ Refractory Multiple Myeloma

Clinical Study for Evaluating ESO-T01 Injection's Safety and Efficacy in Treating Relapsed/refractory Multiple Myeloma


Sponsor

Chunrui Li

Enrollment

24 participants

Start Date

Jan 27, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This is a single center, single arm, open-label, dose-escalation clinical study to observe the safety, tolerability, preliminary efficacy, pharmacokinetics, pharmacodynamics of ESO-T01 injection for treating patients with relapsed/refractory multiple myeloma.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests a new cell therapy called ESO-T01 for people with multiple myeloma — a cancer of the blood — that has come back or stopped responding to other treatments. ESO-T01 uses specially engineered immune cells designed to attack myeloma cells. **You may be eligible if...** - You are 18 or older with confirmed multiple myeloma - Your myeloma has returned or stopped responding after at least 2 prior treatment courses - Your cancer can be measured through blood or urine tests - Your overall health and organ function meet study requirements **You may NOT be eligible if...** - You have had a bone marrow transplant from a donor within the past 6 months, or your own stem cells transplanted in the past 3 months - You have another active cancer - You have serious heart, lung, or liver problems - You have active infections including HIV, hepatitis B, or hepatitis C Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGESO-T01

ESO-T01 injection is the third-generation self-inactivating lentiviral vector targeting T cells in vivo, which carries a single VHH-directed BCMA-targeted CAR.


Locations(1)

Tongji Hospital, Tongji Medical College

Wuhan, Hubei, China

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NCT06791681


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