RecruitingEarly Phase 1NCT06793241

Donor Derived CD19 CAR-T Cells in the Treatment of R/R B-cell Acute Lymphoblastic Leukemia

A Clinical Study on the Safety and Effectiveness of Donor Derived CD19 CAR-T Cells in the Treatment of R/R B-cell Acute Lymphoblastic Leukemia


Sponsor

Zhejiang University

Enrollment

15 participants

Start Date

Jan 31, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

A Clinical Study on the Safety and Effectiveness of donor derived CD19 CAR-T Cells in the treatment of R/R B-cell acute lymphoblastic leukemia


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests a new type of immune cell therapy — CAR-T cells derived from a donor — to treat B-cell acute lymphoblastic leukemia (a fast-growing blood cancer) that has come back or not responded to chemotherapy. This approach is used when a patient's own immune cells cannot be used. **You may be eligible if...** - You are 18 or older and have been diagnosed with B-cell acute lymphoblastic leukemia - Your cancer has relapsed or did not respond after chemotherapy - Standard options such as your own CAR-T cells are not available or did not work - Your cancer cells have a marker called CD19 **You may NOT be eligible if...** - You have serious liver, heart, or lung problems - You have an active uncontrolled infection - Your blood counts are too low Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALCD19 B-cell Acute Lymphoblastic Leukemia Targeted CAR T-cells injection

Each subject receive CD19 B-cell Acute Lymphoblastic Leukemia Targeted CAR T-cells by intravenous infusion


Locations(1)

The first affiliated hospital of medical college of zhejiang university

Hangzhou, Zhejiang, China

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NCT06793241


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