RWE Non-Interventional Prospective Study of Ribociclib Effectiveness and Safety in Patients With HR+/HER2- Early Breast Cancer in Saudi Arabia
Real-world Evidence Non-Interventional proSpective Study of kisqaLi (Ribociclib) Effectiveness and safEty in Patients With HR+/HER2- Early Breast Cancer in Saudi Arabia
Novartis Pharmaceuticals
177 participants
Aug 27, 2025
OBSERVATIONAL
Conditions
Summary
This is a non-interventional, prospective, single-arm, observational study describing the real-world effectiveness, safety, and PRO and HCRU data of ribociclib combined with adjuvant ET under conditions of routine clinical practice in HR+/HER2- EBC in premenopausal, perimenopausal and postmenopausal women, or men in Saudi Arabia.
Eligibility
Inclusion Criteria7
- Signed and dated Patient Informed Consent Form (PICF) obtained.
- The patient is ≥ 18 years-old at the time of PICF signature.
- Male or female patients with estrogen-receptor-positive and/or progesterone-receptor-positive BC.
- Male or female patients with HER2- BC.
- Patients who are currently receiving ribociclib in combination with adjuvant ET as per approved local label for up to 6 months prior the enrollment date.
- Male or female patients with American Joint Committee on Cancer (AJCC) Anatomic Stage Group IIA(subset) /IIB or Anatomic Stage Group III EBC.
- Female patients with known menopausal status (at the time of PICF signature or initiation of adjuvant ET, whichever occurs earlier), or male.
Exclusion Criteria5
- Ribociclib-based treatment regimen beyond adjuvant therapy for EBC.
- Patients are currently participating in any other clinical trials.
- Patients who previously received any other CDK4/6 inhibitor.
- Patients who refused to sign informed consent.
- According to the investigator's opinion, the patient is an unlikely candidate to provide an accurate medical history and/or to obtain long-term follow-up information for any reason.
Interventions
This is an observational study. There is no treatment allocation. The decision to initiate ribociclib will be based solely on clinical judgement.
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT06797531