RecruitingNot ApplicableNCT06797661

Insights Into the Pathophysiology of Neurovascular Uncoupling in Patients with Brain Lesions.

Sponsor

Erasme University Hospital

Enrollment

40 participants

Start Date

Feb 17, 2025

Study Type

INTERVENTIONAL

Conditions

Glioblastoma Glioma Astrocytoma

Summary

Neurovascular uncoupling (NVU) represents a major source of potential bias for the identification of eloquent brain regions through activation procedures in blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI). Same region shows proper pattern in glucose metabolism in victiny of brain lesions, investigated with positron emitted tomography with radiolabeled glucose (PET-FDG) This research project aims at investigating the mechanisms of NVU by using a multimodal noninvasive imaging approach in neurosurgical patients.

Eligibility

Min Age: 18 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This research study investigates why blood flow and brain activity sometimes become "uncoupled" — meaning brain activity and blood supply don't increase together as they normally should — in patients with brain lesions. Understanding this could improve how doctors monitor brain health during and after surgery. **You may be eligible if...** - You have a brain lesion (a mass or growth inside the brain) visible on prior imaging that doctors believe can be surgically removed - You are being enrolled before any surgery, chemotherapy, or radiation **You may NOT be eligible if...** - You have previously had brain surgery - You have respiratory failure, asthma, or claustrophobia - You have diabetes (type I or II) - You have had a prior allergic reaction to gadovist (a contrast dye used in MRI) - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTFunctional MRI

11 minutes of Functional MRI alternating breathing Air-Room and gaz mix (5%CO2 21%O2 74%N2). All procedure are acquired simultaneously on a single acquisition on the PET/MRI camera in the institution.

DIAGNOSTIC_TESTFDG-PET

Some patients who did not benefit from a FDG-PET in their clinical evaluation or more than 1 month before the inclusion in the present study will be ask to also undergo a brain FDG-PET , the dose is set at 2 Mega becquerel per Kg. All procedure are acquired simultaneously on a single acquisition on the PET/MRI camera in the institution.

DIAGNOSTIC_TESTStructural MRI

Patient will benefit Different anatomical sequence of acquisition listed here : T1 , T1 with contrast agent (gadovist) , T2 flair , T2 and DSC (Dynamic susceptibility contrast) , and Time Of Flight . All procedure are acquired simultaneously on a single acquisition on the PET/MRI camera in the institution.