RecruitingPhase 2NCT06800209

Pain Reprocessing Therapy in Post-Operative Knee Pain

Efficacy and Mechanisms of Pain Reprocessing Therapy in Chronic Post-Operative Knee Pain


Sponsor

University of Colorado, Denver

Enrollment

110 participants

Start Date

Aug 13, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn whether Pain Reprocessing Therapy (PRT) can help adults with knee pain after knee replacement surgery. The study is comparing PRT to usual care (the regular treatment people get after surgery) to see which works better for relieving pain. The main questions the study aims to answer are: 1. Does PRT help lower pain in people who have chronic knee pain after knee surgery? 2. How do the effects of PRT compare with usual care in terms of pain relief and other factors such as anxiety, depression, and sleep? 3. How does PRT impact the brain? Participants will: 1. Be randomly assigned to receive either PRT or usual care. 2. Complete questionnaires about their pain and health. 3. If in the PRT group, have eight weekly therapy sessions over video calls with a therapist. 4. If interested, may also take part in an optional EEG test to measure brain activity related to pain.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a behavioral approach called Pain reprocessing therapy (PRT) and Usual care for people with knee pain chronic and pain, chronic. The study is currently recruiting participants at 2 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALPain reprocessing therapy (PRT)

A promising new psychotherapy for chronic pain.

OTHERUsual care

Participants will be asked to continue to do whatever they are currently doing to manage their pain.


Locations(2)

University of Colorado Anschutz Medical Campus

Aurora, Colorado, United States

Hospital for Special Surgery

New York, New York, United States

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NCT06800209


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