RecruitingNCT06800898

Orexin Gene in Anorexia Nervosa

The Methylation Level of the Orexin Gene in Anorexia Nervosa: Relationship With Eating Disorder, Depressive State, and Sleep Quality

Sponsor

Istituto Auxologico Italiano

Enrollment

60 participants

Start Date

Jun 19, 2024

Study Type

OBSERVATIONAL

Conditions

Anorexia Nervosa

Summary

The objectives of this study will be to determine the methylation of the promoter of the Orexin A (OX-A) and B (OX-B) genes in young women (\> 18 years) with Anorexia Nervosa (AN), compared with a control group; and to evaluate the relationship of promoter methylation of the genes for OX-A and OX-B with the severity of the eating disorder, psychiatric comorbidities (in particular, depression), and sleep quality.

Eligibility

Sex: FEMALEMin Age: 18 Years

Inclusion Criteria8

Patients with Anorexia Nervosa:
Female sex
Age 18 years and older
Anorexia Nervosa
Hospitalized at the Division of Eating and Nutrition Disorders, Istituto Auxologico Italiano, IRCCS, Piancavallo, Italy
Female sex
Age 18 years and older
Body Mass Index between 18.5 and 24.9 kg/m2

Exclusion Criteria4

Absence of signed informed consent
Control group:
Absence of signed informed consent
Presence of any physical and mental pathology

Interventions

OTHERBlood samples and Questionnaires

Blood samples for methylation of the promoter of the OX-A and OX-B genes and questionnaires: Eating Disorder Examination Q Eating Disorder Inventory 3 Major Depression Inventory Symptom Checklist-revised ESS - Epworth Sleepiness Scale Pittsburgh Sleep Quality Index Horne \& Ostberg questionnaire