RecruitingNCT06800898

Orexin Gene in Anorexia Nervosa

The Methylation Level of the Orexin Gene in Anorexia Nervosa: Relationship With Eating Disorder, Depressive State, and Sleep Quality

Sponsor

Istituto Auxologico Italiano

Enrollment

60 participants

Start Date

Jun 19, 2024

Study Type

OBSERVATIONAL

Conditions

Anorexia Nervosa

Summary

The objectives of this study will be to determine the methylation of the promoter of the Orexin A (OX-A) and B (OX-B) genes in young women (\> 18 years) with Anorexia Nervosa (AN), compared with a control group; and to evaluate the relationship of promoter methylation of the genes for OX-A and OX-B with the severity of the eating disorder, psychiatric comorbidities (in particular, depression), and sleep quality.

Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether differences in a brain chemical called orexin — which regulates hunger, sleep, and energy — play a role in anorexia nervosa. Researchers will compare gene and blood samples from women with anorexia to healthy women. **You may be eligible if (patients with anorexia)...** - You are a woman aged 18 or older - You have a diagnosis of anorexia nervosa - You are currently hospitalized at the eating disorders unit at Istituto Auxologico Italiano, Italy **You may be eligible if (healthy control group)...** - You are a woman aged 18 or older - Your BMI is between 18.5 and 24.9 (normal weight range) - You have no physical or mental health conditions **You may NOT be eligible if...** - You decline to sign the informed consent form Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERBlood samples and Questionnaires

Blood samples for methylation of the promoter of the OX-A and OX-B genes and questionnaires: Eating Disorder Examination Q Eating Disorder Inventory 3 Major Depression Inventory Symptom Checklist-revised ESS - Epworth Sleepiness Scale Pittsburgh Sleep Quality Index Horne \& Ostberg questionnaire